29/01/2026

SFB1399 Annual Meeting 2026

SFB 1399

Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer

20 Research Projects:

Interdisciplinary, Cross-Faculty Collaboration

SFB1399

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Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype and little progress has been made in understanding the molecular mechanisms causing this devastating disease. No mechanistic explanation exists for a central clinical hallmark: While SCLC typically presents with initial sensitivity against chemotherapy, the disease almost inevitably relapses. Recent discoveries in SCLC genomics and transcriptomics have now provided first mechanistic insight into the biology of this deadly disease. 

Latest Publications

  • Functional synapses between neurons and small cell lung cancer.
    Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. Epub ahead of print. Erratum in: Nature. 2025 Sep 19. doi: 10.1038/s41586-025-09638-z.
    PMID: 40931078
  • DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution.
    Hunold P, Pizzolato G, Heramvand N, Kaiser L, Barbiera G, van Ray O, Thomas R, George J, Peifer M, Hänsel-Hertsch R. Nat Commun. 2025 Jul 28;16(1):6585. doi: 10.1038/s41467-025-61797-9. PMID: 40721574; 
    PMCID: PMC12304361
  • A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade.
    Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886;
    PMCID: PMC11564195
  • TERT Expression and Clinical Outcome in Pulmonary Carcinoids.
    Werr L, Bartenhagen C, Rosswog C, Cartolano M, Voegele C, Sexton-Oates A, Di Genova A, Ernst A, Kahlert Y, Hemstedt N, Höppner S, Mansuet Lupo A, Pelosi G, Brcic L, Papotti M, George J, Bosco G, Quaas A, Tang LH, Robzyk K, Kadota K, Roh MS, Fanaroff RE, Falcon CJ, Büttner R, Lantuejoul S, Rekhtman N, Rudin CM, Travis WD, Alcala N, Fernandez-Cuesta L, Foll M, Peifer M, Thomas RK, Fischer M; Lung NEN Network. J Clin Oncol. 2025 Jan 10;43(2):214-225. doi: 10.1200/JCO.23.02708. Epub 2024 Sep 30. PMID: 39348606; 
    PMCID: PMC11709002
  • CDK9 inhibition as an effective therapy for small cell lung cancer. 
    Valdez Capuccino L, Kleitke T, Szokol B, Svajda L, Martin F, Bonechi F, Krekó M, Azami S, Montinaro A, Wang Y, Nikolov V, Kaiser L, Bonasera D, Saggau J, Scholz T, Schmitt A, Beleggia F, Reinhardt HC, George J, Liccardi G, Walczak H, Tóvári J, Brägelmann J, Montero J, Sos ML, Őrfi L, Peltzer N. Cell Death Dis. 2024 May 20;15(5):345. doi: 10.1038/s41419-024-06724-4. PMID: 38769311; 
    PMCID: PMC11106072
  • Evolutionary trajectories of small cell lung cancer under therapy. 
    George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK. Nature. 2024 Mar;627(8005):880-889. doi: 10.1038/s41586-024-07177-7. Epub 2024 Mar 13. PMID: 38480884;
    PMCID: PMC10972747

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SFB 1399 Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer

SFB 1399 Mechanisms of Drug Sensitivity
and Resistance in Small Cell Lung Cancer

c/o Department of Translational Genomics
University of Cologne
Weyertal 115b
50931 Cologne, Germany

+49-221-478-98776
info[@]sfb1399.de

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University of Cologne University Hospital of Cologne University Hospital Essen TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University Main University of Bonn University of Frankfurt Universitätsmedizin der Johannes Gutenberg-Universität Mainz (JGU) Ludwig-Maximilians-Universität München (LMU) Universität Stuttgart Cologne-Seoul International Research Training Group (CS-IRTG) Deutsche Forschungsgemeinschaft CIO Centrum für integrierte Onkologie Aachen Köln Bonn Düsseldorf Lung Cancer Group Cologne