Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype and little progress has been made in understanding the molecular mechanisms causing this devastating disease. No mechanistic explanation exists for a central clinical hallmark: While SCLC typically presents with initial sensitivity against chemotherapy, the disease almost inevitably relapses. Recent discoveries in SCLC genomics and transcriptomics have now provided first mechanistic insight into the biology of this deadly disease. 

Latest Publications

  • Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
    Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer, Michael Hölzel
    Journal for ImmunoTherapy of Cancer. 2021 May 20
  • Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes.
    Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt & Silvia von Karstedt.
    Nature Communications. 2021 Apr 6, volume 12.
    Article number: 2048 (2021)
  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.
    Stefan C.Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G.Deshwar, KaixianYu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G.Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E.Schumacher, Yu Fan, Matthew Fittall, Ruben M.Drews, Xiaotong Yao, Thomas B.K.Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J.Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C.Boutros, MarcinImielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T.Spellman, Wenyi Wang, Quaid D.Morris, David C.Wedge, Peter Van Loo
    Cell. 2021 Apr 7. ScienceDirect