CV
Dr. nat. med. Filippo Beleggia
Academic education
2010 - 2014: PhD, University of Cologne, Cologne, Germany
2002 - 2010: Medical school, University of Bologna, Bologna, Italy
Scientific degrees
2014: Dr. nat. med. (PhD), University of Cologne. Thesis title: “Innovative strategies for gene identification and analysis of progeria syndromes”, magna cum laude.
2010: MD thesis, University of Bologna. Title: “Analysis of the mitochondrial function in the Down Syndrome”, 110/110 with honors.
Scientific career
05/2021 - present: Junior group leader, Mildred Scheel School of Oncology, University Hospital of Cologne and Department of Translational Genomics, University of Cologne
01/2017 - 05/2021: Postdoc, Department of Internal Medicine I, University Hospital of Cologne 01/2016 - 12/2016: Resident physician, Institute of Human Genetics, University Hospital of
Düsseldorf
01/2015 - 12/2015: Resident physician, Institute of Human Genetics, University Hospital of Cologne
2010 - 2014: PhD student, Institute of Human Genetics and CECAD, University Hospital of Cologne
Honors / Awards / Memberships
2021: Mildred Scheel School of Oncology Junior Group Leader
2010: PhD fellowship from the Cologne Graduate School of Ageing Research
Contact Information
Dr. nat. med. Filippo Beleggia
Junior group leader
University of Cologne
Department of Translational Genomics
10 most relevant publications
- Winkler F, Heuer S, Althammer F, Augustin H, Beleggia F, Demir IE, Koenig J, Kuner R, Kuner T, Loges S, Platten M, Reinhardt HC, Rich JM, Sahm F, Stassart RM, Thiel V, Trumpp A, Venkataramani V, Wick W, Karreman MA. Cancer neuroscience: The past, the present, and the road ahead. Cell. 2026;189(8):2464-2489. doi:10.1016/j.cell.2026.03.018
- Mueller S, de Andrade Krätzig N, Tschurtschenthaler M, Silva MG, Thordsen C, Trozzo R, Simon P, Saab F, Kalten-bacher T, Zukowska M, Lucarelli D, Öllinger R, Griger J, Groß N, Groll T, Löprich J, Zaurito AE, Schömig LR, Bugter JM, Bärthel S, Falcomatà C, Strong A, Brandt C, Najajreh M, Papargyriou A, Maresch R, Collins KAN, Sailer D, Schneeweis C, Burger S, Fröhlich LM, Klement C, Belka A, Montero JJ, Jungwirth U, Reichert M, Moser M, Neumann J, Vassiliou G, Cadiñanos J, Varela I, Marr C, Alonso DF, Lollini PL, Zhao J, Chesler L, Isacke CM, Riedel A, Braun CJ, Sos ML, Beleggia F, Reinhardt HC, Musteanu M, Barbacid M, Quante M, Schmidt-Supprian M, Schneider G, Clare S, Lawley TD, Dougan G, Steiger K, Conte N, Bradley A, Rad L, Saur D, Rad R. A disease model resource reveals core principles of tissue-specific cancer evolution. Nature. 2026;653(8113):265-276. doi:10.1038/s41586-026-10187-2
- Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M*, Rizzoli SO*, Bergami M*, Motori E*, Reinhardt HC*, Beleggia F*. Functional synapses between neurons and small cell lung cancer. Nature. 2025;646(8087):1243-1253. doi:10.1038/s41586-025-09434-9 *joint supervision
- Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S. Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. Nat Commun. 2025;16(1):11280. doi:10.1038/s41467-025-67142-4
- Meder L, Orschel CI, Bouchez CL, Gholamipoorfard R, Orschel C v., Stahl D, Kreer C, Koker M, Nill M, Kocak IG, Noh KW, Zhao X, Ullrich L, Häupl B, Jakob J, Eich ML, Florin A, Grüll H, Wolf J, Beleggia F, Büttner R, Oellerich T, Klein F, Brägelmann J, Reinhardt HC, Abedpour N, Ullrich RT. ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer. Nat Commun. 2025;16(1):10983. doi:10.1038/s41467-025-66800-x
- Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Torres Fernández LA, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu L na, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024;150(11):496. doi:10.1007/s00432-024-05942-9
- Valdez Capuccino L, Kleitke T, Szokol B, Svajda L, Martin F, Bonechi F, Krekó M, Azami S, Montinaro A, Wang Y, Nikolov V, Kaiser L, Bonasera D, Saggau J, Scholz T, Schmitt A, Beleggia F, Reinhardt HC, George J, Liccardi G, Walczak H, Tóvári J, Brägelmann J, Montero J, Sos ML, Őrfi L, Peltzer N. CDK9 inhibition as an effective therapy for small cell lung cancer. Cell Death Dis. 2024;15(5):345. doi:10.1038/s41419-024-06724-4
- Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12(1):2048. doi:10.1038/s41467-021-22336-4
- Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F*, Reinhardt HC*. ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020;34(3):771-786. doi:10.1038/s41375-019-0618-2 *equal contributions
- Jachimowicz RD, Beleggia F*, Isensee J*, Velpula BB*, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019;176(3):505-519.e22. doi:10.1016/j.cell.2018.11.024 *equal contributions
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