CV
Dr. nat. med. Filippo Beleggia
Academic education
2010 - 2014: PhD, University of Cologne, Cologne, Germany
2002 - 2010: Medical school, University of Bologna, Bologna, Italy
Scientific degrees
2014: Dr. nat. med. (PhD), University of Cologne. Thesis title: “Innovative strategies for gene identification and analysis of progeria syndromes”, magna cum laude.
2010: MD thesis, University of Bologna. Title: “Analysis of the mitochondrial function in the Down Syndrome”, 110/110 with honors.
Scientific career
05/2021 - present: Junior group leader, Mildred Scheel School of Oncology, University Hospital of Cologne and Department of Translational Genomics, University of Cologne
01/2017 - 05/2021: Postdoc, Department of Internal Medicine I, University Hospital of Cologne 01/2016 - 12/2016: Resident physician, Institute of Human Genetics, University Hospital of
Düsseldorf
01/2015 - 12/2015: Resident physician, Institute of Human Genetics, University Hospital of Cologne
2010 - 2014: PhD student, Institute of Human Genetics and CECAD, University Hospital of Cologne
Honors / Awards / Memberships
2021: Mildred Scheel School of Oncology Junior Group Leader
2010: PhD fellowship from the Cologne Graduate School of Ageing Research
10 most relevant publications
- Bebber, C. M., Thomas, E. S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M. N., Stüker, L., de Pádua Alves, C., Khonsari, A., Dammert, M. A., Parmaksiz, F., Tumbrink, H. L., Beleggia, F., Sos, M. L., Riemer, J., George, J., Brodesser, S., Thomas, R. K., … von Karstedt, S. (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications, 12(1).
- Riabinska, A., Lehrmann, D., Jachimowicz, R. D., Knittel, G., Fritz, C., Schmitt, A., Geyer, A., Heneweer, C., Wittersheim, M., Frenzel, L. P., Torgovnick, A., Wiederstein, J. L., Wunderlich, C. M., Ortmann, M., Paillard, A., Wößmann, W., Borkhardt, A., Burdach, S., Hansmann, M. L., …, Beleggia, F.*, Reinhardt, H. C*. (2020). ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia, 34(3), 771–786. *contributed equally
- Ragamin, A., Yigit, G., Bousset, K., Beleggia, F., Verheijen, F. W., de Wit, M. C. Y., Strom, T. M., Dörk, T., Wollnik, B., & Mancini, G. M. S. (2020). Human RAD50 deficiency: Confirmation of a distinctive phenotype.American Journal of Medical Genetics, Part A, 182(6), 1378–1386.
- Jachimowicz, R. D., Beleggia, F.*, Isensee, J.*, Velpula, B. B.*, Goergens, J., Bustos, M. A., Doll, M. A., Shenoy, A., Checa-Rodriguez, C., Wiederstein, J. L., Baranes-Bachar, K., Bartenhagen, C., Hertwig, F., Teper, N., Nishi, T., Schmitt, A.,Distelmaier, F., Lüdecke, H. J., Albrecht, B., … Shiloh, Y. (2019). UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell, 176(3), 505-519.e22. *contributed equally
- Erber, J., Steiner, J. D., Isensee, J., Lobbes, L. A., Toschka, A., Beleggia, F., Schmitt, A., Kaiser, R. W. J., Siedek, F., Persigehl, T., Hucho, T., & Reinhardt, H. C. (2019). Dual inhibition of GLUT1 and the ATR/Chk1 kinase axis displays synergistic cytotoxicity in KRAS-mutant cancer cells. Cancer Research, 79(19).
- Torgovnick, A., Heger, J. M., Liaki, V., Isensee, J., Schmitt, A., Knittel, G., Riabinska, A., Beleggia, F., Laurien, L., Leeser, U., Jüngst, C., Siedek, F., Vogel, W., Klümper, N., Nolte, H., Wittersheim, M., Tharun, L., Castiglione, R., Krüger, M., … Reinhardt, H. C. (2018). The Cdkn1a SUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Reports,25(4), 1027-1039.e6.
- Knittel, G., Rehkämper, T., Korovkina, D., Liedgens, P., Fritz, C., Torgovnick, A., Al-Baldawi, Y., Al- Maarri, M., Cun, Y., Fedorchenko, O., Riabinska, A., Beleggia, F., Nguyen, P. H., Wunderlich, F. T., Ortmann, M., Montesinos-Rongen, M.,Tausch, E., Stilgenbauer, S., Frenzel, L. P., … Reinhardt, H.C. (2017). Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nature Communications, 8(1).
- Doerr, F., George, J., Schmitt, A., Beleggia, F., Rehkämper, T., Hermann, S., Walter, V., Weber, J. P., Thomas, R. K., Wittersheim, M., Büttner, R., Persigehl, T., & Christian Reinhardt, H. (2017). Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. Scientific Reports, 7(1).
- Hatzold, J., Beleggia, F., Herzig, H., Altmüller, J., Nürnberg, P., Bloch, W., Wollnik, B., & Hammerschmidt, M. (2016). Tumor suppression in basal keratinocytes via dual non-cell- autonomous functions of a Na,K-ATPasebeta subunit. ELife, 5.
- Beleggia, F., Li, Y., Fan, J., Elcioğlu, N. H., Toker, E., Wieland, T., Maumenee, I. H., Akarsu, N. A., Meitinger, T., Strom, T. M., Lang, R., & Wollnik, B. (2015). CRIM1 haploinsufficiency causes defects in eye development in human and mouse.Human Molecular Genetics, 24(8), 2267–2273.
Contact Information
Dr. nat. med. Filippo Beleggia
Junior group leader
University of Cologne
Department of Translational Genomics
