CV

Univ. Prof. Dr. med. Matthias Fischer

Academic education

1991 - 1999: Medical School, University of Cologne

Scientific degrees

07/2007: Habilitation in Pediatrics, Faculty of Medicine, University of Cologne
06/2002: M.D., Medical School, University of Cologne, Summa cum Laude: “Charakterisierung der Antikörpergene humaner CD5-positiver B-Zellen und Plasmazellen der Darmschleimhaut mittels Einzelzell-PCR” (Supervisor: Ralf Küppers, PhD; Department I for Internal Medicine, University of Cologne, Head: Volker Diehl, M.D.)
05/1999: Graduation from Medical School, University of Cologne, Summa cum Laude

Scientific career

2016 - present: W2 Professorship, Head of the Department of Experimental Pediatric Oncology, University of Cologne
2015 - 2016: Research period at the Max-Planck-Institute for Metabolism Research, Cologne (Laboratory Prof. Dr. J. Brüning)
2014 - present: Deputy head of the Department of Pediatric Oncology, University Hospital of Cologne
2013: Appointment as Professor for Pediatrics, University of Cologne
2009 - present: Consultant pediatric oncologist, University Hospital of Cologne
2006: Board examination pediatrics
2005 - 2009: Resident physician, Department of Pediatric Oncology, University Hospital of Cologne
2001 - 2015: Independent research group leader, Department of Pediatric Oncology, University Hospital of Cologne
1999 - 2005: Resident physician, Department of Pediatrics, University Hospital of Cologne

Honors/ Awards/ Memberships

2018: Adalbert-Czerny Award, German Society of Pediatrics and Adolescent Medicine (DGKJ)
2018: Elected member of the ANRA Steering Committee
2017: Board of Directors of the international Massive Analysis and Quality Control (MAQC) Society
2017: Head of the national Biobank Neuroblastoma
2017: Principal Investigator at the Center for Molecular Medicine Cologne (CMMC), University of Cologne
2016: Gerhard-Domagk-Award 2016, Gerhard Domagk-Stiftung, Münster
2015: Board member of the Center for Integrated Oncology (CIO) Köln-Bonn
2014: Member of the Trial Committee of the Registry Individualized Therapy for Relapsed Malignancies in Childhood (INFORM)
2014: Elected member of the international Advances in Neuroblastoma Research Association (ANRA) Advisory Board
2011: Member of the International Neuroblastoma Response Criteria (INPC) and the International Neuroblastoma Risk Group (INRG) consortia
2011: Member of the national Neuroblastoma Trial Committee
1994 - 1998: Scholar of the Studienstiftung des Deutschen Volkes

10 most relevant publications

  • Ackermann S, Cartolano M, Hero B, Welte A, Y Kahlert, Roderwieser A, Bartenhagen C, Walter E, Gecht J, Kerschke L, Volland R, Menon R, Heuckmann JM, Gartlgruber M, Hartlieb S, Henrich KO, Okonechnikov K, Altmüller J, Nürnberg P, Lefever S, de Wilde B, Sand F, Ikram F, Rosswog C, Fischer J, Theissen J, Hertwig F, Singhi AD, Simon T, Vogel W, Perner S, Krug B, Schmidt M, Rahmann S, Achter V, Lang U, Vokuhl C, Ortmann M, Büttner R, Eggert A, Speleman F, O’Sullivan RJ, Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH, Peifer M, Fischer M. A mechanistic classification of clinical phenotypes in neuroblastoma. Sciencein press.
  • Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann J, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Glöckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O’Sullivan RJ, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature, 2015, 526: 700-704.
  • Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schröder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmüller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S*, Fischer M*, Eggert A*, Schulte JH*. Mutational dynamics between primary and relapse neuroblastomas. Nat Genet, 2015, 47(8): 872-877; *equal contribution.
  • Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, Zhang W, Thierry-Mieg D, Wang J, Furlanello C, Devanarayan V, Cheng J, Deng Y, Hero B, Hong H, Jia M, Li L, Lin SM, Nikolsky Y, Oberthuer A, Qing T, Su Z, Volland R, Wang C, Wang MD, Ai J, Albanese D, Asgharzadeh S, Avigad S, Bao W, Bessarabova M, Brilliant MH, Brors B, Chierici M, Chu TM, Zhang J, Grundy RG, He MM, Hebbring S, Kaufman HL, Lababidi S, Lancashire LJ, Li Y, Lu XX, Luo H, Ma X, Ning B, Noguera R, Peifer M, Phan JH, Roels F, Rosswog C, Shao S, Shen J, Theissen J, Tonini GP, Vandesompele J, Wu PY, Xiao W, Xu J, Xu W, Xuan J, Yang Y, Ye Z, Dong Z, Zhang KK, Yin Y, Zhao C, Zheng Y, Wolfinger RD, Shi T, Malkas LH, Berthold F, Wang J, Tong W, Shi L, Peng Z, Fischer M. Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biol, 2015, 16(1): 133. 
  • Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wuestefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M. Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles. Nature, 2014, 511(7510): 483-487.
  • Su Z, Fang H, Hong H, Shi L, Zhang W, Zhang W, Zhang Y, Dong Z, Lancashire LJ, Bessarabova M, Yang X, Ning B, Gong B, Meehan J, Xu J, Ge W, Perkins R, Fischer M*, Tong W*. An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era. Genome Biol, 2014, 15(12): 523; *co-corresponding author.
  • Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet, 2012, 44(10): 1104-10.
  • Ackermann S, Goeser F, Schulte JH, Schramm A, Ehemann V, Eggert A, Hero B, Berthold F, Fischer M. Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma. Clin Cancer Res, 2011, 17(4): 731-741.
  • Oberthuer A, Hero B, Berthold F, Juraeva D, Faldum A, Kahlert Y, Asgharzadeh S, Seeger R, Scaruffi P, Tonini GP,Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Vermeulen J, Speleman F, Noguera R, Piqueras M,Bénard J, Valent A, Avigad S, Yaniv I, Weber A, Christiansen H, Grundy RG, Schardt K, Schwab M, Eils R, Warnat P, Kaderali L, Simon T, DeCarolis B, Theissen J, Westermann F, Brors B, Fischer M. Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol, 2010, 28: 3506-3515.
  • Oberthür A, Berthold F, Warnat P, Hero B, Kahlert Y, Spitz R, Ernestus K, König R, Haas S, Eils R, Schwab M, Brors B, Westermann F, Fischer M. Customized oligonucleotide microarray gene-expression based classification of neuroblastoma patients outperforms current clinical risk stratification. J Clin Oncol, 2006, 24: 5070-5078.

Contact Information

Univ. Prof. Dr. med. Matthias Fischer SFB1399
Univ. Prof. Dr. med. Matthias Fischer

Professor (W2) and Head of the Department of Experimental Pediatric Oncology

University Hospital of Cologne

Department of Experimental Pediatric Oncology

Center for Molecular Medicine Cologne (CMMC)

Curriculum Vitae (CV)

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