Univ. Prof. Dr. med. Katrin Paeschke

Academic education

2001 – 2003 Diploma Biochemistry, University of Witten Herdecke, thesis supervisor: Prof. Dr. H.J. Lipps

1999 – 2001 Vordiplom Biology, University of Bonn

Scientific degrees

2003 – 2006 Dr. rer. nat., Cell Biology, University of Witten Herdecke, thesis supervisor: Prof. Dr. H.J. Lipps and Prof. Dr. D. Rhodes

Scientific career

2018 – present Professor (W2), Translational Oncology, Department of Oncology, University of Hospital Bonn, Germany

2016 – 2017 Associate Professor at the University Medical Clinic Groningen (UMCG)
European Research Institute for the Biology of Ageing (ERIBA)
Focus: G-quadruplex DNA structures and DNA damage and DNA repair

2012 – 2017 Emmy Noether Group leader at the University of Würzburg, Germany
Focus: G-quadruplex structures and interacting proteins

2007 – 2011 Postdoctoral researcher, Princeton University, Department of Molecular Biology, USA

Focus: G-quadruplex structures, helicases and genome stability

Honors / Awards / Memberships

2015 Walther Flemming Medal of the German Society of Cell Biology

2014 ERC Starting Grant (G4 DSB)

2012 Roentgen Award for young scientist, University of Würzburg, Germany

2012 DFG Heinz-Maier-Leibnitz Award

2012 Emil Fischer Fellow, University of Würzburg, Germany

2011 DFG Emmy Noether Fellowship

Contact Information

Univ.-Prof. Dr. rer. nat. Katrin Paeschke SFB1399
Univ.-Prof. Dr. rer. nat. Katrin Paeschke

Tenured professor (W2), Research Group leader

University Hospital Bonn

Department of Oncology and Hematology

Curriculum Vitae (CV)

10 most relevant publications

  • Pandey, S, Hajiakzemi M, Zacheja, T, Schalbetter S, Baxter J, Guryev V, Hofmann A, Herrmann DW, Juranek SA*, Paeschke K* (2021) Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage. BMC Biology. doi: 10.1186/s12915-021-01167-1
  • De Magis, A., Kastl, M., Brossart, P., Heine, A. & Paeschke, K. , (2021) BG-Flow, a New Flow Cytometry Tool for G-Quadruplex Quantification in Fixed Cells. BMC Biology 19,45. doi:10.1186/s12915-021-00986-6
  • Kosiol N., Juranek S, Brossart P, Heine A, Paeschke K, (2021) G-quadruplexes: A Promising Target for Cancer Therapy, Molecular Cancer 20:40 doi: 10.1186/s12943-021-01328-4
  • Zacheja T#, Toth A#, Harami GM, Yang Q, Schwindt E, Kovács M, Paeschke K*, Burkovics P*. Mgs1 protein supports genome stability via recognition of G-quadruplex DNA structures. FASEB J. 2020 Sep;34(9):12646-12662. doi: 10.1096/fj.202000886R. Epub 2020 Aug 4. PMID: 32748509.
  • DeMagis A, Götz S, Hajikazemi M, Fekete-Szücs E, Caterino M, Juranek S.A. Paeschke K* (2020) Zuo1 supports G4 structure formation and directs repair towards nucleotide excision repair. Nature Communications, 11:3907,
  • Sauer M, Juranek SA, Marks J, De Magis A, Kazemier HG, Hilbig D, Benhalevy D, Wang X, Hafner M*, Paeschke K* (2019) DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions. Nature Communications 10: 2421.
  • Wanzek K, Schwindt E, Capra JA, Paeschke K* (2017) Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability. Nucleic Acids Research 45: 7796–7806.
  • Paeschke K#, Bochman ML#, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8. PMID: 23657261; PMCID: PMC3680789..

  • Bochman ML#, Paeschke K#, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet. 2012 Nov;13(11):770-80. doi: 10.1038/nrg3296. Epub 2012 Oct 3. PMID: 23032257; PMCID: PMC3725559.

  • Paeschke K#, Capra JA, Zakian VA. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell. 2011 May 27;145(5):678-91. doi: 10.1016/j.cell.2011.04.015. PMID: 21620135; PMCID: PMC3129610.

    # first authorship
    * corresponding authorship.