CV
Dr. rer. nat. Christina M. Bebber
Academic education
2018-2021: PhD in Biology, University of Cologne
2012-2018: B.Sc. in Biology at the University of Bonn and M.Sc. in Molecular Biotechnology and the Goethe University Frankfurt and the SDU University of Southern Denmark
Scientific degrees
12/2021: Ph.D. in Biology, University of Cologne
09/2018: Master of Science, Goethe University Frankfurt
09/2015: Bachelor of Science, University of Bonn
Scientific career
01/2022-04/2022 Visiting Postdoctoral Researcher at Stanford University (Group of Prof. Dr. Julien Sage)
Since 01/2022 Postdoctoral Researcher at University of Cologne (Group of Prof. Dr. Silvia von Karstedt)
Honors/ Awards/ Memberships:
2025: Poster prize Cologne Lung Cancer Conference
2025: Poster prize New York Academy of Sciences “Cancer metabolism and signaling in the TME”
2024: Start-up funding Grant SPP2306 “Ferroptosis: from Molecular Basics to Clinical Applications”, “Markers of lipid peroxidation and ferroptosis sensitivity in metastasis to liver and lung”
2022, 2023, 2024: Travel Grant SFB1399 “Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer”
2021: Exchange Program Grant SFB1399 “Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer”
2020: Start-up Funding SFB1399 “Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer”
2020: Cancers Best Paper Award
10 most relevant publications
- Tishina S, Dahlhaus A, Manik M, Mulalic L, Murr J, Kotliar M, Rakhsh-Khorshid H, Kostopoulou M, Hocher F, Stroh J, Beck J, Williams RM, Balta GG, Liu F, Abdallah AT, Bebber CM, Reese M, Lim JKM, Quaas A, Brägelmann J, Pasparakis M, Beleggia F, Balachandran S, Trauzold A, Liccardi G, Astsaturov I, Reichert M, Androulidaki A, von Karstedt S. Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis. Nat Commun. 2026;17(1):5288. doi:10.1038/s41467-026-73189-8
- Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S. Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. Nat Commun. 2025;16(1):11280. doi:10.1038/s41467-025-67142-4
- Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025;646(8087):1243-1253.
doi:10.1038/s41586-025-09434-9
- Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025;32(11):1986-2008. doi:10.1038/s41418-025-01517-4
- Müller F, Lim JKM, Bebber CM, Seidel E, Tishina S, Dahlhaus A, Stroh J, Beck J, Yapici FI, Nakayama K, Torres Fernández LA, Brägelmann J, Leprivier G, von Karstedt S. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ. 2023;30(2):442-456. doi:10.1038/s41418-022-01096-8
- Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton A v., Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in health and disease. Redox Biol. 2024;75:103211. doi:10.1016/j.redox.2024.103211
- Yapici FI*, Bebber CM*, von Karstedt S. A guide to ferroptosis in cancer. Mol Oncol. 2024;18(6):1378-1396. doi:10.1002/1878-0261.13649 *equal contribution
- Bebber CM, von Karstedt S. FSP1 inhibition: pick your pocket. Nat Struct Mol Biol. 2023;30(11):1618-1619. doi:10.1038/s41594-023-01145-x
- Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12(1):2048. doi:10.1038/s41467-021-22336-4
- Bebber CM, Müller F, Prieto Clemente L, Weber J, von Karstedt S. Ferroptosis in Cancer Cell Biology. Cancers (Basel). 2020;12(1):164. doi:10.3390/cancers12010164
Contact Information
Dr. rer. nat. Christina M. Bebber
Junior Group Leader
University of Cologne
Department of Translational Genomics
CECAD Research Center
