CV
Univ. Prof. Dr. rer. nat. Manolis Pasparakis
Academic education
1987 - 1992: Undergraduate Studies in Biology (Diploma), University of Athens
Scientific degrees
09/1997: PhD in Biology, University of Athens; experimental work performed at the Hellenic Pasteur Institute, “Study of the biology of Tumor Necrosis Factor (TNF) and its receptors in transgenic systems” (Supervisor: Dr. George Kollias)
07/1992: Diploma in Biology, University of Athens
Scientific career
2005 - present: W3 full professorship, Institute for Genetics, University of Cologne
2002 - 2005: Independent Group Leader, Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo (Rome), Italy
1997 - 2001: Postdoctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne (Group of Professor Dr. Klaus Rajewsky)
Honors/ Awards/ Memberships
2018: Advanced Grant, European Research Council (ERC)
2013: Advanced Grant, European Research Council (ERC)
2011: Editorial Board, EMBO Molecular Medicine
2008: Elected Member, European Molecular Biology Organization (EMBO)
2000: Special Postdoctoral Fellowship (2 years), The Leukemia & Lymphoma Society, Institute for Genetics, University of Cologne
1997: Long Term EMBO Fellowship (2 years), Institute for Genetics, University of Cologne
1996: Short-term EMBO Fellowship, Department of Cell Biology and Immunology, Free University of Amsterdam, The Netherlands
1993: Short-term EMBO Fellowship, Department of Biochemistry & Molecular Genetics, St. Mary’s Hospital Medical School, London, UK
10 most important original publications
- Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A, Pasparakis M. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 1;540(7631):124-128
- Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M. NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions. Immunity. 2016 Mar 15;44(3):553-567
- Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van T-M, Curth H-M, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M, NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Dec 14;28(6):830
- Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4;513(7516):90-4
- Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature. 2011 Jul 31;477(7364):330-4
- Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity. 2011 Oct 28;35(4):572-82
- Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007 Mar 29;446(7135):557-61
- Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell. 2007 Feb;11(2):119-32
- van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol. 2006 Sep;7(9):954-61
- Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6
Contact Information
Univ. Prof. Dr. rer. nat. Manolis Pasparakis
Professor (W3)
University of Cologne
Institute for Genetics
CECAD Research Center
