CV
Univ. Prof. Dr. rer. nat. Stefan Knapp
Academic education
1987 - 1990: Chemistry, University of Marburg, Germany and University of Illinois, USA
Scientific degrees
1992: Diploma (Chemistry) Mentor: Prof M. Beato (Marburg)
1992 - 1996: PhD thesis, Karolinska Institute, Stockholm, Sweden, Mentor: Prof. Dr. R. Ladenstein
Scientific career
2017 - present: CSO of the Structural Genomics Consortium site at Frankfurt University
2015 - present: Professor for Pharmaceutical Chemistry (W3), GU, Frankfurt, Germany
2012 - 2015: Director of Chemical Biology, Target Discovery Institute (TDI), Nuffield Department of Clinical Medicine, University of Oxford, UK
2008 - 2015: Professor of Structural Biology, Nuffield Department of Clinical Medicine, University of Oxford, UK
2004 - present: Principal Investigator, Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, UK
1999 - 2004: Principal Scientists, Chemistry and Structural Biology, Pharmacia Corp. Nerviano, Italy
1996 - 1999: Postdoctoral Fellow, Karolinska Institute, Stockholm, Sweden
Honors/ Awards/ Memberships
2018: Elected member of EMBO Society
2017: Biochemical Society Award
2014: Rita and John Cornforth Award of the Royal Society of Chemistry
2012: Fellow of the American Chemical Society
1997: Boehringer Ingelheim Fellowship
2012 - present: Member of the American Chemical Society
Patents
- 2003: Interaction inhibitors of Tcf-4 with beta-catenin. WO03006447, WO2003006447 A220030123
- 2003: Truncated human dbf4 in complex with its interacting partners (catalytic subunits) such as human cdc7, and methods for the production of monodisperse heterodimers for identification and optimization of inhibitors thereof. WO/2004/099243
Contact Information
Univ. Prof. Dr. rer. nat. Stefan Knapp
Professor of Pharmaceutical Chemistry (W3) and site head SGC (Structural Genomics Consortium Frankfurt)
Goethe-Universität Frankfurt
Institute for Pharmaceutical Chemistry
10 most relevant publications
- Mitrović M, Greco FA, García YC, Lučić A, Hoffmann L, Chander R, Schönfeld J, Liebisch N, Sivashanmugam SA, Schwalm MP, Egner M, Lewandowski M, Merk D, Morasch V, Wolf E, Müller S, Hanke T, Proschak E, Hiesinger K, Knapp S. Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery. J Med Chem. 2026;69(3):2599-2624. doi:10.1021/acs.jmedchem.5c02543
- Schwalm MP, Krämer A, Dölle A, Weckesser J, Yu X, Jin J, Saxena K, Knapp S. Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol. 2023;30(7):753-765.e8. doi:10.1016/j.chembiol.2023.06.002
- Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE. Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction. Nature. 2020;588(7837):344-349. doi:10.1038/s41586-020-2673-2
- Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S*, Lemmon MA*. Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. Mol Cell. 2020;79(3):390-405.e7. doi:10.1016/j.molcel.2020.06.018 *corresponding authors
- Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S*, Wolf E*. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nat ChemBiol. 2020;16(11):1179-1188. doi:10.1038/s41589-020-00652-y *corresponding authors
- Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S. A chemical toolbox for the study of bromodomains and epigenetic signaling. Nat Commun. 2019;10(1):1915. doi:10.1038/s41467-019-09672-2
- Chaikuad A, Koch P, Laufer SA, Knapp S. The Cysteinome of Protein Kinases as a Target in Drug Development. Angewandte Chemie International Edition. 2018;57(16):4372-4385. doi:10.1002/anie.201707875
- Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family. Cell. 2012;149(1):214-231. doi:10.1016/j.cell.2012.02.013
- Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, la Thangue N, French CA, Wiest O, Kung AL, Knapp S*, Bradner JE*. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067-1073. doi:10.1038/nature09504 *corresponding authors
- Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation. Cell. 2008;134(5):793-803. doi:10.1016/j.cell.2008.07.047
