Publications / Reviews

2025

Functional synapses between neurons and small cell lung cancer.
Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Ianicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. Epub ahead of print. Erratum in: Nature. 2025 Sep 19. doi: 10.1038/s41586-025-09638-z.
PMID: 40931078.
Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments.
Rose F, Ibruli O, Lichius L, Kiljan M, Gozum G, Caiaffa MI, Cai J, Niu LN, Herter JM, Grüll H, Büttner R, Beleggia F, Bosco G, George J, Herter-Sprie GS, Reinhardt HC, Bozek K. BMC Res Notes. 2025 Sep 8;18(1):385. doi: 10.1186/s13104-025-07460-4. PMID: 40922010;
PMCID: PMC12418687.
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution.
Hunold P, Pizzolato G, Heramvand N, Kaiser L, Barbiera G, van Ray O, Thomas R, George J, Peifer M, Hänsel-Hertsch R. Nat Commun. 2025 Jul 28;16(1):6585. doi: 10.1038/s41467-025-61797-9. PMID: 40721574;
PMCID: PMC12304361.
CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma.
Stahl D, Gödel P, Balke-Want H, Gholamipoorfard R, Segbers P, Tetenborg L, Koker M, Dörr J, Gregor L, Bachurski D, Rose F, Simon AG, Good Z, Jakob J, Häupl B, Nill M, Flümann R, Riet T, Lange D, Blakemore SJ, Baurmann H, Voltin CA, Potter N, Schlözer L, Freihammer M, Wagener-Ryczek S, Iuga AI, Heger JM, Ludwig H, Schleifenbaum JK, Propp J, Bröckelmann PJ, Jachimowicz RD, Knittel G, Borchmann S, Merkelbach-Bruse S, Pallasch C, Peifer M, Rybniker J, Quaas A, Nitz M, Brägelmann J, Müller W, Persigehl T, Bozek K, Theobald SJ, Büttner R, Oellerich T, Hallek M, Kobold S, Chmielewski M, Reinhardt HC, Mackall C, Abedpour N, Borchmann P, Ullrich RT. Cancer Cell. 2025 Aug 11;43(8):1476-1494.e10. doi: 10.1016/j.ccell.2025.05.013. Epub 2025 Jun 12.
PMID: 40513575.
TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model.
Gewalt T, Dmitrieva AM, Elsner F, Zhao X, Sieber DD, Kocak IG, Yang Q, Orschel CV, Eckert NM, Goebel B, Nill M, Peter F, Hartmann A, Beleggia F, Odenthal M, Reinhardt HC, Ullrich RT, Graw F, Meder L. Commun Biol. 2025 May 13;8(1):741. doi: 10.1038/s42003-025-08146-0. PMID: 40360735;
PMCID: PMC12075843.

2024

Dual inhibition of HERs and PD-1 counteract resistance in KRASG12C-mutant head and neck cancer.
Novoplansky O, Jagadeeshan S, Prasad M, Yegodayev KM, Marripati D, Shareb RA, Greenshpan Y, Mathukkada S, Ben-Lulu T, Bhattacharya B, Porgador A, Kong D, Brägelmann J, Gutkind JS, Elkabets M. J Exp Clin Cancer Res. 2024 Nov 20;43(1):308. doi: 10.1186/s13046-024-03227-0. PMID: 39567998;
PMCID: PMC11577641.
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade.
Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886;
PMCID: PMC11564195.
Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score.
Arolt C, Scheel AH, Dugan M, Wild R, Richartz V, Holz B, Brägelmann J, Wagener-Ryczek S, Merkelbach-Bruse S, Wolf J, Buettner R, Catanzariti L, Scheffler M, Hillmer AM. NPJ Precis Oncol. 2024 Nov 11;8(1):259. doi: 10.1038/s41698-024-00744-1. PMID: 39528799;
PMCID: PMC11554772.
TERT Expression and Clinical Outcome in Pulmonary Carcinoids.
Werr L, Bartenhagen C, Rosswog C, Cartolano M, Voegele C, Sexton-Oates A, Di Genova A, Ernst A, Kahlert Y, Hemstedt N, Höppner S, Mansuet Lupo A, Pelosi G, Brcic L, Papotti M, George J, Bosco G, Quaas A, Tang LH, Robzyk K, Kadota K, Roh MS, Fanaroff RE, Falcon CJ, Büttner R, Lantuejoul S, Rekhtman N, Rudin CM, Travis WD, Alcala N, Fernandez-Cuesta L, Foll M, Peifer M, Thomas RK, Fischer M; Lung NEN Network. J Clin Oncol. 2025 Jan 10;43(2):214-225. doi: 10.1200/JCO.23.02708. Epub 2024 Sep 30. PMID: 39348606;
PMCID: PMC11709002.
Next-generation lung cancer pathology: Development and validation of diagnostic and prognostic algorithms.
Kludt C, Wang Y, Ahmad W, Bychkov A, Fukuoka J, Gaisa N, Kühnel M, Jonigk D, Pryalukhin A, Mairinger F, Klein F, Schultheis AM, Seper A, Hulla W, Brägelmann J, Michels S, Klein S, Quaas A, Büttner R, Tolkach Y. Cell Rep Med. 2024 Sep 17;5(9):101697. doi: 10.1016/j.xcrm.2024.101697. Epub 2024 Aug 22. PMID: 39178857;
PMCID: PMC11524894.
Clinicopathologic and molecular characteristics of small-scale ROS1-mutant non-small cell lung cancer (NSCLC) patients.
Glaser M, Rasokat A, Prang D, Nogova L, Wömpner C, Schmitz J, Bitter E, Terjung I, Eisert A, Fischer R, John F, von Levetzow C, Michels S, Riedel R, Ruge L, Scharpenseel H, Siebolts U, Merkelbach-Bruse S, Buettner R, Brägelmann J, Wolf J, Scheffler M.Lung Cancer. 2023 Oct;184:107344. doi: 10.1016/j.lungcan.2023.107344. Epub 2023 Aug 12.
PMID: 37579577.
Telomere maintenance mechanisms in neuroblastoma: New insights and translational implications.
Werr L, Rosswog C, Bartenhagen C, George SL, Fischer M. EJC Paediatric Oncology. 2024 June. Volume 3, 2024, 100156. doi: 10.1016/j.ejcped.2024.100156 (Review)
Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.
Meder L, Orschel CI, Otto CJ, Koker M, Brägelmann J, Ercanoglu MS, Dähling S, Compes A, Selenz C, Nill M, Dietlein F, Florin A, Eich ML, Borchmann S, Odenthal M, Blazquez R, Hilberg F, Klein F, Hallek M, Büttner R, Reinhardt HC, Ullrich RT. JCI Insight. 2024 May 22;9(10):e166402. doi: 10.1172/jci.insight.166402. PMID: 38775153;
PMCID: PMC11141935.
CDK9 inhibition as an effective therapy for small cell lung cancer.
Valdez Capuccino L, Kleitke T, Szokol B, Svajda L, Martin F, Bonechi F, Krekó M, Azami S, Montinaro A, Wang Y, Nikolov V, Kaiser L, Bonasera D, Saggau J, Scholz T, Schmitt A, Beleggia F, Reinhardt HC, George J, Liccardi G, Walczak H, Tóvári J, Brägelmann J, Montero J, Sos ML, Őrfi L, Peltzer N. Cell Death Dis. 2024 May 20;15(5):345. doi: 10.1038/s41419-024-06724-4. PMID: 38769311;
PMCID: PMC11106072.
Evolutionary trajectories of small cell lung cancer under therapy.
George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK. Nature. 2024 Mar;627(8005):880-889. doi: 10.1038/s41586-024-07177-7. Epub 2024 Mar 13. PMID: 38480884;
PMCID: PMC10972747.

2023

Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer.Malchers F, Nogova L, van Attekum MH, Maas L, Brägelmann J, Bartenhagen C, Girard L, Bosco G, Dahmen I, Michels S, Weeden CE, Scheel AH, Meder L, Golfmann K, Schuldt P, Siemanowski J, Rehker J, Merkelbach-Bruse S, Menon R, Gautschi O, Heuckmann JM, Brambilla E, Asselin-Labat ML, Persigehl T, Minna JD, Walczak H, Ullrich RT, Fischer M, Reinhardt HC, Wolf J, Büttner R, Peifer M, George J, Thomas RK. J Clin Invest. 2023 Nov 1;133(21):e170217. doi: 10.1172/JCI170217. PMID: 37606995; PMCID: PMC10617767.
Predicting HPV association using deep learning and regular H&E stains allows granular stratification of oropharyngeal cancer patients.Klein S, Wuerdemann N, Demers I, Kopp C, Quantius J, Charpentier A, Tolkach Y, Brinker K, Sharma SJ, George J, Hess J, Stögbauer F, Lacko M, Struijlaart M, van den Hout MFCM, Wagner S, Wittekindt C, Langer C, Arens C, Buettner R, Quaas A, Reinhardt HC, Speel EJ, Klussmann JP. NPJ Digit Med. 2023 Aug 19;6(1):152. doi: 10.1038/s41746-023-00901-z. PMID: 37598255;
PMCID: PMC10439941.
Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer.
Müller N, Lorenz C, Ostendorp J, Heisel FS, Friese UP, Cartolano M, Plenker D, Tumbrink H, Heimsoeth A, Baedeker P, Weiss J, Ortiz-Cuaran S, Büttner R, Peifer M, Thomas RK, Sos ML, Berg J, Brägelmann J. Cancer Res. 2023 Aug 1;83(15):2471-2479. doi: 10.1158/0008-5472.CAN-22-2605.
PMID: 37289018.
KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC.
Arolt C, Dugan M, Wild R, Richartz V, Holz B, Scheel AH, Brägelmann J, Wagener-Ryczek S, Merkelbach-Bruse S, Wolf J, Buettner R, Catanzariti L, Scheffler M, Hillmer AM. J Thorac Oncol. 2023 Nov;18(11):1550-1567. doi: 10.1016/j.jtho.2023.07.016. Epub 2023 Jul 18.
PMID: 37473958.
Intratumoral abundance of M2-macrophages is associated with unfavorable prognosis and markers of T-cell exhaustion in small cell lung cancer patients.
Klein S, Schulte A, Arolt C, Tolkach Y, Reinhardt H. C, Buettner R, Quaas A. Mod Pathol. 2023 Jul 7;100272. doi: 10.1016/j.modpat.2023.100272
PMID: 37423586
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Koerner L, Schmiel M, Yang TP, Peifer M, Buettner R, Pasparakis M. Cell Death Differ. 2023 Jan 18. doi: 10.1038/s41418-023-01112-5. Epub ahead of print.
PMID: 36653597
Staining of activated ß2-integrins in combination with CD137 and CD154 for sensitive identification of functional antigen-specific CD4+ and CD8+ T cells.
Schöllhorn A, Maia A, Kimmerle F, Born J, Rammensee H-G, Dimitrov S and Gouttefangeas C. Front. Immunol. 2023 Jan. 13:1107366. doi: 10.3389/fimmu.2022.1107366

2022

CAF-immune cell crosstalk and its impact in immunotherapy.
Maia A, Schöllhorn A, Schuhmacher J, Gouttefangeas C. Semin Immunopathol. 2022 Dec 8. doi: 10.1007/s00281-022-00977-x.
PMID: 36480035
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation.
Müller F, Lim JKM, Bebber CM, Seidel E, Tishina S, Dahlhaus A, Stroh J, Beck J, Yapici FI, Nakayama K, Torres Fernández L, Brägelmann J, Leprivier G, von Karstedt S. Cell Death Differ. 2023 Feb;30(2):442-456. doi: 10.1038/s41418-022-01096-8. Epub 2022 Nov 29. PMID: 36443441;
PMCID: PMC9950476.
Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors
Borchmann S, Selenz C, Lohmann M, Ludwig H, Gassa A, Brägelmann J, Lohneis P, Meder L, Mattlener J, Breid S, Nill M, Fassunke J, Wisdom AJ, Compes A, Gathof B, Alakus H, Kirsch D, Hekmat K, Büttner R, Reinhardt HC, Hallek M, Ullrich RT. J Immunother Cancer. 2022 Oct;10(10):e004781. doi: 10.1136/jitc-2022-004781.
PMID: 36223955
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S. J Med Chem. 2022 Sep 22. doi: 10.1021/acs.jmedchem.2c01106. Epub ahead of print.
PMID: 36136092
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Hluchý M, Gajdušková P, Ruiz de Los Mozos I, Rájecký M, Kluge M, Berger BT, Slabá Z, Potěšil D, Weiß E, Ule J, Zdráhal Z, Knapp S, Paruch K, Friedel CC, Blazek D. Nature. 2022 Sep;609(7928):829-834. doi: 10.1038/s41586-022-05204-z. Epub 2022 Sep 14.
PMID: 36104565
PROTAC degraders as chemical probes for studying target biology and target validation.
Němec V, Schwalm MP, Müller S, Knapp S. Chem Soc Rev. 2022 Sep 20;51(18):7971-7993. doi: 10.1039/d2cs00478j.
PMID: 36004812
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
Gremke N, Polo P, Dort A, Schneikert J, Elmshäuser S, Brehm C, Klingmüller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7.
PMID: 32943635
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. Nat Commun. 2020 Aug 17;11(1):4124. doi: 10.1038/s41467-020-17958-z.
PMID: 32807787
EGFR Inhibition Strongly Modulates the Tumour Immune Microenvironment in EGFR-Driven Non-Small-Cell Lung Cancer.
Selenz C, Compes A, Nill M, Borchmann S, Odenthal M, Florin A, Brägelmann J, Büttner R, Meder L, Ullrich RT. Cancers (Basel). 2022 Aug 16;14(16):3943. doi: 10.3390/cancers14163943. PMID: 36010935;
PMCID: PMC9406398.
Normics: Proteomic Normalization by Variance and Data-Inherent Correlation Structure.
Dressler FF, Brägelmann J, Reischl M, Perner S. Mol Cell Proteomics. 2022 Sep;21(9):100269. doi: 10.1016/j.mcpro.2022.100269. Epub 2022 Jul 16. PMID: 35853575;
PMCID: PMC9450154.
Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
Ratz L, Brambillasca C, Bartke L, Huetzen MA, Goergens J, Leidecker O, Jachimowicz RD, van de Ven M, Proost N, Siteur B, de Korte-Grimmerink R, Bouwman P, Pulver EM, de Bruijn R, Isensee J, Hucho T, Pandey G, van Lohuizen M, Mallmann P, Reinhardt HC, Jonkers J, Puppe J. Breast Cancer Res. 2022 Jun 17;24(1):41. doi: 10.1186/s13058-022-01534-y.
PMID: 35715861
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Schwalm MP, Berger LM, Meuter MN, Vasta JD, Corona CR, Röhm S, Berger BT, Farges F, Beinert SM, Preuss F, Morasch V, Rogov VV, Mathea S, Saxena K, Robers MB, Müller S, Knapp S. Front Cell Dev Biol. 2022 May 26;10:886537. doi: 10.3389/fcell.2022.886537.
PMID: 35721509
Integrin activation enables rapid detection of functional Vδ1⁺ and Vδ2⁺ γδ T cells
Herold N, Schöllhorn A, Feile A, Gaißler A, Mohrholz A, Pawelec G, Löffler MW, Dimitrov S, Gouttefangeas C, Wistuba-Hamprecht K. Eur J Immunol. 2022 May;52(5):730-736. doi: 10.1002/eji.202149682. Epub 2022 Feb 21.
PMID: 35133647
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles
Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, Mathea S, Berger LM, Berger BT, Krämer A, Weller M, Weiss T, Müller S, Knapp S, Hanke T. J Med Chem. 2022 Jun 9;65(11):7799-7817. doi: 10.1021/acs.jmedchem.2c00173. Epub 2022 May 24.
PMID: 35608370
Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
Offermann A, Joerg V, Becker F, Roesch MC, Kang D, Lemster AL, Tharun L, Behrends J, Merseburger AS, Culig Z, Sailer V, Brägelmann J, Kirfel J, Perner S. Am J Pathol. 2022 May;192(5):813-823. doi: 10.1016/j.ajpath.2022.01.010. Epub 2022 Feb 16.
PMID: 35181333.
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors
Lategahn J, Tumbrink HL, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, Keul M, Parmaksiz F, Baumann M, Menninger S, Zent E, Landel I, Weisner J, Jeyakumar K, Heyden L, Russ N, Müller F, Lorenz C, Brägelmann J, Spille I, Grabe T, Müller MP, Heuckmann JM, Klebl BM, Nussbaumer P, Sos ML, Rauh D. J Med Chem. 2022 May 12;65(9):6643-6655. doi: 10.1021/acs.jmedchem.1c02080. Epub 2022 Apr 29.
PMID: 35486541.
Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT.
Lemster AL, Sievers E, Pasternack H, Lazar-Karsten P, Klümper N, Sailer V, Offermann A, Brägelmann J, Perner S, Kirfel J. Cancers (Basel). 2022 Apr 8;14(8):1894. doi: 10.3390/cancers14081894. PMID: 35454801;
PMCID: PMC9032772.
CD74-NRG1 fusions are oncogenic in vivo and induce therapeutically tractable ERBB2:ERBB3 heterodimerization
Werr L, Plenker D, Dammert M A., Lorenz C, Brägelmann J, Tumbrink H L., Klein S, Schmitt A, Büttner R, Persigehl T, Shokat K M., Wunderlich T, Schram A M., Peifer M, Sos M L, Reinhardt H C., Thomas R K.
Mol Cancer Ther. 2022 Feb
PMID: 35247925
Resistance to kinase inhibition through shortened target engagement.
Rangwala AM, Berger BT, Robers MB, Knapp S, Seeliger MA. Mol Cell Oncol. 2022 Jan 22;9(1):2029999. doi: 10.1080/23723556.2022.2029999. PMCID: PMC8890393.
PMID: 35252553
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Baltzer S, Bulatov T, Schmied C, Krämer A, Berger BT, Oder A, Walker-Gray R, Kuschke C, Zühlke K, Eichhorst J, Lehmann M, Knapp S, Weston J, von Kries JP, Süssmuth RD, Klussmann E. Int J Mol Sci. 2022 Jan 11;23(2):763. doi: 10.3390/ijms23020763. PMCID: PMC8776063.
PMID: 35054947
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. J Med Chem. 2022 Jan 27;65(2):1370-1383. doi: 10.1021/acs.jmedchem.1c00848. Epub 2021 Oct 20. ; PMCID: PMC9255384.
PMID: 34668706

2021

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer. Schaufler D, Ast DF, Tumbrink HL, Abedpour N, Maas L, Schwäbe AE, Spille I, Lennartz S, Fassunke J, Aldea M, Besse B, Planchard D, Nogova L, Michels S, Kobe C, Persigehl T, Westphal T, Koleczko S, Fischer R, Weber JP, Altmüller J, Thomas RK, Merkelbach-Bruse S, Gautschi O, Mezquita L, Büttner R, Wolf J, Peifer M, Brägelmann J, Scheffler M, Sos ML. NPJ Precis Oncol. 2021 Dec 17;5(1):102. doi: 10.1038/s41698-021-00241-9.
PMID: 34921211
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
Rosswog C, Bartenhagen C, Welte A, Kahlert Y, Hemstedt N, Lorenz W, Cartolano M, Ackermann S, Perner S, Vogel W, Altmüller J, Nürnberg P, Hertwig F, Göhring G, Lilienweiss E, Stütz AM, Korbel JO, Thomas RK, Peifer M, Fischer M.
Nat Genet. 2021 Dec;53(12):1673-1685. doi: 10.1038/s41588-021-00951-7. Epub 2021 Nov 15.
PMID: 34782764
Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.
Robers MB, Wilkinson JM, Vasta JD, Berger LM, Berger BT, Knapp S. STAR Protoc. 2021 Sep 15;2(4):100822. doi: 10.1016/j.xpro.2021.100822.; PMCID: PMC8449129.
PMID: 34568844
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML. Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8.
PMID: 34535668
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.
Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, Kuster B, Sotriffer C, Wolf E, Knapp S. J Med Chem. 2021 Aug 12;64(15):10682-10710. doi: 10.1021/acs.jmedchem.1c00146. Epub 2021 May 13. PMID: 33980013
Trends in kinase drug discovery: targets, indications and inhibitor design. Attwood MM, Fabbro D, Sokolov AV, Knapp S, Schiöth HB. Nat Rev Drug Discov. 2021 Nov;20(11):839-861. doi: 10.1038/s41573-021-00252-y. Epub 2021 Aug 5. Erratum in: Nat Rev Drug Discov. 2021 Oct;20(10):798.
PMID: 34354255.
Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer.
Brägelmann J, Barahona Ponce C, Marcelain K, Roessler S, Goeppert B, Gallegos I, Colombo A, Sanhueza V, Morales E, Rivera MT, de Toro G, Ortega A, Müller B, Gabler F, Scherer D, Waldenberger M, Reischl E, Boekstegers F, Garate-Calderon V, Umu SU, Rounge TB, Popanda O, Lorenzo Bermejo J. Hepatology. 2021 Jun;73(6):2293-2310. doi: 10.1002/hep.31585. Epub 2021 Jun 15.
PMID: 33020926.

Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Hudecova I, Smith CG, Hänsel-Hertsch R, Chilamakuri C, Morris JA, Vijayaraghavan A, Heider K, Chandrananda D, Cooper WN, Gale D, Garcia-Corbacho J, Pacey SC, Baird R, Rosenfeld N, Mouliere F.
Genome Res. 2021 Dec 20:gr.275691.121. PMID: 34930798
DOI: 10.1101/gr.275691.121
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Lyczek A, Berger BT, Rangwala AM, Paung Y, Tom J, Philipose H, Guo J, Albanese SK, Robers MB, Knapp S, Chodera JD, Seeliger MA. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2111451118. doi: 10.1073/pnas.2111451118. PMCID: PMC8609647
PMID: 34750265

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S. J Med Chem. 2021 Sep 23;64(18):13451-13474. doi: 10.1021/acs.jmedchem.1c00868. Epub 2021 Sep 10.
PMID: 34506142
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Serafim RAM, Sorrell FJ, Berger BT, Collins RJ, Vasconcelos SNS, Massirer KB, Knapp S, Bennett J, Fedorov O, Patel H, Zuercher WJ, Elkins JM. J Med Chem. 2021 Sep 23;64(18):13259-13278. doi: 10.1021/acs.jmedchem.0c01579. Epub 2021 Aug 31.
PMID: 34463505
Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC)
Bebber CM, von Karstedt S.
Mol Cell Oncol. 2021 Jul 5;8(4):1933871. doi: 10.1080/23723556.2021.1933871
PMID: 34616869

Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S. J Med Chem. 2021 Jun 24;64(12):8142-8160. doi: 10.1021/acs.jmedchem.0c02144. Epub 2021 Jun 4.
PMID: 34086472.
Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer, Michael Hölzel
Journal for ImmunoTherapy of Cancer. 2021 May 20
Published as: 10.1136/jitc-2020-001335

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt & Silvia von Karstedt
Nature Communications. 2021 Apr 6, volume 12,
Article number: 2048 (2021)

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Stefan C.Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G.Deshwar, KaixianYu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G.Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E.Schumacher, Yu Fan, Matthew Fittall, Ruben M.Drews, Xiaotong Yao, Thomas B.K.Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J.Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C.Boutros, MarcinImielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T.Spellman, Wenyi Wang, Quaid D.Morris, David C.Wedge, Peter Van Loo
Cell. 2021 Apr 7. ScienceDirect.
In Press

Integrin Activation Enables Sensitive Detection of Functional CD4 + and CD8 + T Cells: Application to Characterize SARS-CoV-2 Immunity
Anna Schöllhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T R Jensen, Stefan Stevanović, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cécile Gouttefangeas, Stoyan Dimitrov
Front Immunol, 2021 Mar 29;12:626308. doi: 10.3389/fimmu.2021.626308
PMID: 33854501

CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy
Jennifer R Richardson, Anna Schöllhorn, Cécile Gouttefangeas, Juliane Schuhmacher
Cancers (Basel). 2021 Feb 3;13(4):596.doi: 10.3390/cancers13040596
PMID: 33546283

Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains
Klein S, Quaas A, Quantius J, Löser H, Meinel J, Peifer M, Wagner S, Gattenlöhner S, Wittekindt C, von Knebel Doeberitz M, Prigge ES, Langer C, Noh KW, Maltseva M, Reinhardt HC, Büttner R, Klussmann JP, Wuerdemann N.
Clin Cancer Res. 2021 Feb 15;27(4):1131-1138. doi: 10.1158/1078-0432.CCR-20-3596. Epub 2020 Dec 1
PMID: 33262137

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT.
Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734.
PMID: 33538798

Texture analysis of iodine maps and conventional images for k-nearest neighbor classification of benign and metastatic lung nodules
Lennartz S, Mager A, Große Hokamp N, Schäfer S, Zopfs D, Maintz D, Reinhardt HC, Thomas RK, Caldeira L, Persigehl T.
Cancer Imaging. 2021 Jan 26;21(1):17. doi: 10.1186/s40644-020-00374-3.
PMID: 33499939

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities
Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G.
Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059.
PMID: 33447829
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S. Cell Chem Biol. 2021 May 20;28(5):686-698.e7. doi: 10.1016/j.chembiol.2021.01.003. Epub 2021 Jan 25.
PMID: 33497606

2020

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Lohneis P, Masswig S, Denker S, Busse A, Knittel G, Flümann R, Childs D, Childs L, Gätjens-Sanchez AM, Bullinger L, Rosenwald A, Reinhardt HC, Schmitt CA.
Blood. 2020 Nov 24:blood.2020005244. doi: 10.1182/blood.2020005244.
PMID: 33232972

CaMuS: simultaneous fitting and de novo imputation of cancer mutational signature.
Cartolano M, Abedpour N, Achter V, Yang TP, Ackermann S, Fischer M, Peifer M. Sci Rep. 2020 Nov 9;10(1):19316. doi: 10.1038/s41598-020-75753-8.
PMID: 33168834
Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome.
Chen Y, Hoffmeister LM, Zaun Y, Arnold L, Schmid KW, Giebel B, Klein-Hitpass L, Hanenberg H, Squire A, Reinhardt HC, Dührsen U, Bertram S, Hanoun M.
Blood Adv. 2020 Oct 27;4(20):5257-5268. doi: 10.1182/bloodadvances.2020001808.
PMID: 33108453

Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective.
Jakobs F, Drost RMWA, Kron A, Heinen J, Hallek M, Reinhardt HC, Zander T, Kron F.
Oncol Res Treat. 2020;43(10):498-505. doi: 10.1159/000509618. Epub 2020 Sep 21
PMID: 32957103

Landscape of G-quadruplex DNA structural regions in breast cancer.
Hänsel-Hertsch R, Simeone A, Shea A, Hui WWI, Zyner KG, Marsico G, Rueda OM, Bruna A, Martin A, Zhang X, Adhikari S, Tannahill D, Caldas C, Balasubramanian S.
Nat Genet. 2020 Sep;52(9):878-883. doi: 10.1038/s41588-020-0672-8. Epub 2020 Aug 3.
PMID: 32747825

Integrin activation enables simultaneous and sensitive detection of functional virus-specific CD4+ and CD8+ T cells.
Anna Schöllhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T.R. Jensen,
Stefan Stevanović, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cécile Gouttefangeas, Stoyan Dimitrov
Research Square
DOI: 10.21203/rs.3.rs-67111/v1

Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy.
Klein S, Quaas A, Noh KW, Cartolano M, Abedpour N, Mauch C, Quantius J, Reinhardt HC, Buettner R, Peifer M, Helbig D.
Clin Cancer Res. 2020 Aug 17. doi: 10.1158/1078-0432.CCR-20-1899. Epub ahead of print.
PMID: 32817080

Precision medicine in non-small cell lung cancer: Current applications and future directions.
Yang SR, Schultheis AM, Yu H, Mandelker D, Ladanyi M, Büttner R.
Semin Cancer Biol. 2020 Jul 27:S1044-579X(20)30164-4. doi: 10.1016
PMID: 32730814 Review

Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels.
Roider T, Seufert J, Uvarovskii A, Frauhammer F, Bordas M, Abedpour N, Stolarczyk M, Mallm JP, Herbst SA, Bruch PM, Balke-Want H, Hundemer M, Rippe K, Goeppert B, Seiffert M, Brors B, Mechtersheimer G, Zenz T, Peifer M, Chapuy B, Schlesner M, Müller-Tidow C, Fröhling S, Huber W, Anders S, Dietrich S.
Nat Cell Biol. 2020 Jul;22(7):896-906. doi: 10.1038/s41556-020-0532-x. Epub 2020 Jun 15.
PMID: 32541878

New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
John T Poirier, Julie George, Taofeek K Owonikoko, Anton Berns, Elisabeth Brambilla, Lauren A Byers, David Carbone, Huanhuan J Chen, Camilla L Christensen, Caroline Dive, Anna F Farago, Ramaswamy Govindan, Christine Hann, Matthew D Hellmann, Leora Horn, Jane E Johnson, Young S Ju, Sumin Kang, Mark Krasnow, James Lee, Se-Hoon Lee, Jonathan Lehman, Benjamin Lok, Christine Lovly, David MacPherson, David McFadden, John Minna, Matthew Oser, Keunchil Park, Kwon-Sik Park, Yves Pommier, Vito Quaranta , Neal Ready, Julien Sage, Giorgio Scagliotti, Martin L Sos, Kate D Sutherland, William D Travis, Christopher R Vakoc, Sarah J Wait, Ignacio Wistuba, Kwok Kin Wong, Hua Zhang, Jillian Daigneault, Jacinta Wiens, Charles M Rudin, Trudy G Oliver.
J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016
PMID: 32018053

Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells
Torsten Thalheim, Lydia Hopp, Maria Herberg, Susann Siebert, Christiane Kerner, Marianne Quaas, Michal R Schweiger, Gabriela Aust, Joerg Galle.
Int J Mol Sci. 2020 Mar 12;21(6):1941.
PMID: 32178409

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.
Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F, Reinhardt HC.
Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2. Epub 2019 Nov 5.
PMID: 31690822

The evolutionary history of 2,658 cancers.
Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD; PCAWG Evolution & Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P; PCAWG Consortium.
Nature. 2020 Feb;578(7793):122-128. doi: 10.1038/s41586-019-1907-7. Epub 2020 Feb 6.
PMID: 32025013

2019

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML.
Nat Commun. 2019 Aug 2;10(1):3485. doi: 10.1038/s41467-019-11371-x.
PMID: 31375684

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors
Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Müller G, Tesch R, Kudolo M, Forster M, Laufer S, Knapp S. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62(23):10757-10782. doi: 10.1021/acs.jmedchem.9b01227. Epub 2019 Nov 26. PMID: 31702918.
PMID: 31702918
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.
Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9
PMID: 30926931