Publications / Reviews

2021

  • Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
    Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer, Michael Hölzel
    Journal for ImmunoTherapy of Cancer. 2021 May 20
    Published as: 10.1136/jitc-2020-001335
  • Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
    Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt & Silvia von Karstedt
    Nature Communications. 2021 Apr 6, volume 12,
    Article number: 2048 (2021)
  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
    Stefan C.Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G.Deshwar, KaixianYu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G.Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E.Schumacher, Yu Fan, Matthew Fittall, Ruben M.Drews, Xiaotong Yao, Thomas B.K.Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J.Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C.Boutros, MarcinImielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T.Spellman, Wenyi Wang, Quaid D.Morris, David C.Wedge, Peter Van Loo
    Cell. 2021 Apr 7. ScienceDirect.
    In Press
  • Integrin Activation Enables Sensitive Detection of Functional CD4 + and CD8 + T Cells: Application to Characterize SARS-CoV-2 Immunity
    Anna Schöllhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T R Jensen, Stefan Stevanović, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cécile Gouttefangeas, Stoyan Dimitrov
    Front Immunol, 2021 Mar 29;12:626308. doi: 10.3389/fimmu.2021.626308
    PMID: 33854501
  • CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy
    Jennifer R Richardson, Anna Schöllhorn, Cécile Gouttefangeas, Juliane Schuhmacher
    Cancers (Basel). 2021 Feb 3;13(4):596.doi: 10.3390/cancers13040596
    PMID: 33546283
  • Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains
    Klein S, Quaas A, Quantius J, Löser H, Meinel J, Peifer M, Wagner S, Gattenlöhner S, Wittekindt C, von Knebel Doeberitz M, Prigge ES, Langer C, Noh KW, Maltseva M, Reinhardt HC, Büttner R, Klussmann JP, Wuerdemann N.
    Clin Cancer Res. 2021 Feb 15;27(4):1131-1138. doi: 10.1158/1078-0432.CCR-20-3596. Epub 2020 Dec 1
    PMID: 33262137
  • Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT.
    Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734.
    PMID: 33538798
  • Texture analysis of iodine maps and conventional images for k-nearest neighbor classification of benign and metastatic lung nodules
    Lennartz S, Mager A, Große Hokamp N, Schäfer S, Zopfs D, Maintz D, Reinhardt HC, Thomas RK, Caldeira L, Persigehl T.
    Cancer Imaging. 2021 Jan 26;21(1):17. doi: 10.1186/s40644-020-00374-3.
    PMID: 33499939
  • An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities
    Flümann R, Rehkämper T, Nieper P, Pfeiffer P, Holzem A, Klein S, Bhatia S, Kochanek M, Kisis I, Pelzer BW, Ahlert H, Hauer J, da Palma Guerreiro A, Ryan JA, Reimann M, Riabinska A, Wiederstein J, Krüger M, Deckert M, Altmüller J, Klatt AR, Frenzel LP, Pasqualucci L, Béguelin W, Melnick AM, Sander S, Montesinos-Rongen M, Brunn A, Lohneis P, Büttner R, Kashkar H, Borkhardt A, Letai A, Persigehl T, Peifer M, Schmitt CA, Reinhardt HC, Knittel G.
    Blood Cancer Discov. 2021 Jan;2(1):70-91. doi: 10.1158/2643-3230.BCD-19-0059.
    PMID: 33447829

2020

  • Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
    Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Lohneis P, Masswig S, Denker S, Busse A, Knittel G, Flümann R, Childs D, Childs L, Gätjens-Sanchez AM, Bullinger L, Rosenwald A, Reinhardt HC, Schmitt CA.
    Blood. 2020 Nov 24:blood.2020005244. doi: 10.1182/blood.2020005244.
    PMID: 33232972
  • Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome.
    Chen Y, Hoffmeister LM, Zaun Y, Arnold L, Schmid KW, Giebel B, Klein-Hitpass L, Hanenberg H, Squire A, Reinhardt HC, Dührsen U, Bertram S, Hanoun M.
    Blood Adv. 2020 Oct 27;4(20):5257-5268. doi: 10.1182/bloodadvances.2020001808.
    PMID: 33108453
  • Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective.
    Jakobs F, Drost RMWA, Kron A, Heinen J, Hallek M, Reinhardt HC, Zander T, Kron F.
    Oncol Res Treat. 2020;43(10):498-505. doi: 10.1159/000509618. Epub 2020 Sep 21
    PMID: 32957103
  • Landscape of G-quadruplex DNA structural regions in breast cancer.
    Hänsel-Hertsch R, Simeone A, Shea A, Hui WWI, Zyner KG, Marsico G, Rueda OM, Bruna A, Martin A, Zhang X, Adhikari S, Tannahill D, Caldas C, Balasubramanian S.
    Nat Genet. 2020 Sep;52(9):878-883. doi: 10.1038/s41588-020-0672-8. Epub 2020 Aug 3.
    PMID: 32747825
  • Integrin activation enables simultaneous and sensitive detection of functional virus-specific CD4+ and CD8+ T cells.
    Anna Schöllhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T.R. Jensen, 
    Stefan Stevanović, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cécile Gouttefangeas, Stoyan Dimitrov
    Research Square
    DOI: 10.21203/rs.3.rs-67111/v1
  • Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy.
    Klein S, Quaas A, Noh KW, Cartolano M, Abedpour N, Mauch C, Quantius J, Reinhardt HC, Buettner R, Peifer M, Helbig D.
    Clin Cancer Res. 2020 Aug 17. doi: 10.1158/1078-0432.CCR-20-1899. Epub ahead of print.
    PMID: 32817080
  • Precision medicine in non-small cell lung cancer: Current applications and future directions.
    Yang SR, Schultheis AM, Yu H, Mandelker D, Ladanyi M, Büttner R.
    Semin Cancer Biol. 2020 Jul 27:S1044-579X(20)30164-4. doi: 10.1016
    PMID: 32730814 Review

  • Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels.
    Roider T, Seufert J, Uvarovskii A, Frauhammer F, Bordas M, Abedpour N, Stolarczyk M, Mallm JP, Herbst SA, Bruch PM, Balke-Want H, Hundemer M, Rippe K, Goeppert B, Seiffert M, Brors B, Mechtersheimer G, Zenz T, Peifer M, Chapuy B, Schlesner M, Müller-Tidow C, Fröhling S, Huber W, Anders S, Dietrich S.
    Nat Cell Biol. 2020 Jul;22(7):896-906. doi: 10.1038/s41556-020-0532-x. Epub 2020 Jun 15.
    PMID: 32541878
  • New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
    John T Poirier, Julie George, Taofeek K Owonikoko, Anton Berns, Elisabeth Brambilla, Lauren A Byers, David Carbone, Huanhuan J Chen, Camilla L Christensen, Caroline Dive, Anna F Farago, Ramaswamy Govindan, Christine Hann, Matthew D Hellmann, Leora Horn, Jane E Johnson, Young S Ju, Sumin Kang, Mark Krasnow, James Lee, Se-Hoon Lee, Jonathan Lehman, Benjamin Lok, Christine Lovly, David MacPherson, David McFadden, John Minna, Matthew Oser, Keunchil Park, Kwon-Sik Park, Yves Pommier, Vito Quaranta , Neal Ready, Julien Sage, Giorgio Scagliotti, Martin L Sos, Kate D Sutherland, William D Travis, Christopher R Vakoc, Sarah J Wait, Ignacio Wistuba, Kwok Kin Wong, Hua Zhang, Jillian Daigneault, Jacinta Wiens, Charles M Rudin, Trudy G Oliver.
    J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016
    PMID: 32018053

 

  • Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells
    Torsten Thalheim, Lydia Hopp, Maria Herberg, Susann Siebert, Christiane Kerner, Marianne Quaas, Michal R Schweiger, Gabriela Aust, Joerg Galle.
    Int J Mol Sci. 2020 Mar 12;21(6):1941.
    PMID: 32178409
  • ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.
    Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Wößmann W, Borkhardt A, Burdach S, Hansmann ML, Rosenwald A, Perner S, Mall G, Klapper W, Merseburg A, Krüger M, Grüll H, Persigehl T, Wunderlich FT, Peifer M, Utermöhlen O, Büttner R, Beleggia F, Reinhardt HC.
    Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2. Epub 2019 Nov 5.
    PMID: 31690822
  • The evolutionary history of 2,658 cancers.
    Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD; PCAWG Evolution & Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P; PCAWG Consortium.
    Nature. 2020 Feb;578(7793):122-128. doi: 10.1038/s41586-019-1907-7. Epub 2020 Feb 6.
    PMID: 32025013

2019

  • MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
    Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML.
    Nat Commun. 2019 Aug 2;10(1):3485. doi: 10.1038/s41467-019-11371-x.
    PMID: 31375684
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
    Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.
    Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9
    PMID: 30926931