CV
Univ. Prof. Dr. med. H. Christian Reinhardt
Academic education
1996 - 2003: Medical School, University of Hamburg, Humboldt University Berlin and University of Freiburg
Scientific degrees
05/2012: Professor for Clinical and Molecular Oncology (W2), University Hospital Cologne
11/2008: Habilitation in Experimental Internal Medicine, University of Cologne
06/2003: MD thesis, Department of Internal Medicine, Division 4, University of Freiburg, Advisor: Prof. Dr. H. Pavenstädt (Grade: Summa cum laude)
06/2003: Graduation from Medical School, University of Freiburg (Grade: Summa cum laude)
Scientific career
11/2018: Speaker of the Mildred-Scheel School of Oncology Cologne-Bonn
6/2017: Executive attending physician at the Medical Clinic I of the University Hospital Cologne
3/2017: Speaker of the Else Kröner Forschungskolleg: Clonal evolution in cancer
6/2016: Certified Clinical Trials Manager
08/2015: Attending physician (Oberarzt) at the Medical Clinic I, University Hospital Cologne
05/2015: Board exam (certified in general internal medicine and hematology/medical oncology)
01/2015: Elected member of the executive board of the Center for Molecular Medicine Cologne
01/2013: Head of the Clinical Research Unit-286 “Exploiting defects in the DNA damage response for the treatment of chronic lymphocytic leukemia”
01/2012: Elected member of the steering committee of the Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC)
06/2012: Scientific coordinator of Research Area C within the Excellence Cluster CECAD
01/2012: Lichtenberg Professor for Clinical and Molecular Oncology, University Cologne
11/2009: Emmy-Noether research group leader at the Medical Clinic I, University Cologne
12/2004 - 10/2009: Postdoctoral Associate, MIT, Department of Biology, Koch Institute (Profs. M. B. Yaffe, MD, PhD and T. Jacks, PhD)
01/2004 - 11/2004: Postdoctoral Research Fellow, University of Münster (Prof. H. Pavenstädt)
06/2003 - 12/2003: Postdoctoral Research Fellow University of Freiburg, (Profs. G. Walz and T. Benzing)
Honors/ Awards/ Memberships
2017: Gilead Research Award Oncology
2016: Theodor Frerichs Award of the German Society of Internal Medicine
2012: GlaxoSmithKline Research Award
2011: Vincenz Czerny Award of the German Society for Hematology and Oncology
2011: W2 Lichtenberg Professorship of the VolkswagenStiftung
2011: Research Award of the Central European Society for Anticancer Drug Research
2011: Johann-Georg-Zimmermann Award for Cancer Research
2010: Young Leaders in Science Award of the Schering Stiftung
2009: Emmy-Noether fellowship of the Deutsche Forschungsgemeinschaft
2009: Startup grant Ministerium für Innovation, Wissenschaft, Forschung und Technologie, NRW
2009: NIH/NCI K99/R00 PI award (relinquished due to return to Germany)
2007: MIT-Koch Award
2005: Research fellowship of the Deutsche Forschungsgemeinschaft
2004: Young investigator award of the Deutsche Nierenstiftung
Contact Information
Univ. Prof. Dr. med. H. Christian Reinhardt
Director
University Hospital Essen
Department of Hematology and Stem Cell Transplantation
10 most relevant publications
- Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M*, Rizzoli SO*, Bergami M*, Motori E*, Reinhardt HC*#, Beleggia F*. Functional synapses between neurons and small cell lung cancer. Nature. 2025;646(8087):1243-1253. doi:10.1038/s41586-025-09434-9 *shared last authors, #lead author contact
- George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK. Evolutionary trajectories of small cell lung cancer under therapy. Nature. 2024;627(8005):880-889. doi:10.1038/s41586-024-07177-7
- Dobersalske C, Rauschenbach L, Hua Y, Berliner C, Steinbach A, Grüneboom A, Kokkaliaris KD, Heiland DH, Berger P, Langer S, Tan CL, Stenzel M, Landolsi S, Weber F, Darkwah Oppong M, Werner RA, Gull H, Schröder T, Linsenmann T, Buck AK, Gunzer M, Stuschke M, Keyvani K, Forsting M, Glas M, Kipnis J, Steindler DA, Reinhardt HC, Green EW, Platten M, Tasdogan A, Herrmann K, Rambow F, Cima I, Sure U, Scheffler B. Cranioencephalic functional lymphoid units in glioblastoma. Nat Med. 2024;30(10):2947-2956. doi:10.1038/s41591-024-03152-x
- Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC*#, Wieczorek D*, Shiloh Y*. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019;176(3):505-519.e22. doi:10.1016/j.cell.2018.11.024 *shared last authors, #lead author contact
- Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber ANR, Trümper L, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC. B-cell–specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood. 2016;127(22):2732-2741. doi:10.1182/blood-2015-11-684183
- George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi C min, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, San-delin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt HC, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015;524(7563):47-53. doi:10.1038/nature14664
- Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Cell. 2015;162(1):146-159. doi:10.1016/j.cell.2015.05.053
- Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC. A Functional Cancer Genomics Screen Identifies a Druggable Synthetic Lethal Interaction between MSH3 and PRKDC. Cancer Discov. 2014;4(5):592-605. doi:10.1158/2159-8290.CD-13-0907
- Janes KA*, Reinhardt HC*, Yaffe MB. Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength. Cell. 2008;135(2):343-354. doi:10.1016/j.cell.2008.08.034 *equal contributions
- Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage. Cancer Cell. 2007;11(2):175-189. doi:10.1016/j.ccr.2006.11.024
Patents
- Inventors: Michael B. Yaffe, Isaac A. Manke, Daniel Lim, Hans Christian Reinhardt, USPTO Application #:20090010927
Title: MAPKAP KINASE-2 AS A SPECIFIC TARGET FOR BLOCKING PROLIFERATION OF P53-DEFECTIVE CELLS
Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders
