CV
Univ.-Prof. Dr. rer. nat. Silvia von Karstedt
Academic education
2003 - 2008: Undergraduate Studies in Biology, University of Hamburg (Pre-Diploma) and Heidelberg (Diploma)
Scientific degrees
03/2013: Ph.D. in Biology, Imperial College London, UK; “DISC-dependent versus DISC-independent aspects of TRAIL biology” (Supervisor: Prof. Dr. Henning Walczak)
09/2008: Diploma in Biology, University of Heidelberg
Scientific career
2021 - present: W2 Professor for “Dynamics of Cancer and Immune Systems” at the Department of Translational Genomics/CECAD, University of Cologne, Germany
2017 - 2021: Max Eder Junior Research Group Leader, Department of Translational Genomics / CECAD, University of Cologne, Germany
2016 - 2017: Postdoctoral Research Fellow, The Francis Crick Institute, London, UK (Group of Prof. Julian Downward)
2013 - 2016: Postdoctoral Research Fellow, UCL Cancer Institute, London, UK (Group of Professor Henning Walczak)
Honors/ Awards/ Memberships
2020: Editorial board of Cell Death Discovery
2020: Reviewer for Molecular Cell
2019: Member of the International Association for the Study of Lung Cancer (IASLC)
2019: Member of the European Cell Death Organization (ECDO)
2019: Reviewer board for Cancers and Cells
2018: Board member of the Mildred-Scheel Junior Research Center Cologne
2018: Editorial advisory board of Encyclopaedia Life Science (eLS-Wiley)
2017: Reviewer board for Oncogene and Cell Death and Disease
2015: Member of the EACR
2015: F1000 prize for best short talk, 9th Tuscany Retreat on Cancer Research, Chiusi, Italy
2015: EACR Poster Prize 31st Genes and Cancer Meeting, Cambridge, UK
2014: Poster Prize UCL Cancer Institute 7th Annual Conference, UK
2014: “Prize for best contributing student or postdoc” Gordon Research Conference, Mount Snow, USA
2014: Prize for best selected short talk, 30th Genes and Cancer Meeting, Cambridge, UK
2013: Poster Prize UCL Cancer Institute 6th Annual Conference, UK
2013: Travel Award 14th International TNF-meeting, Quebec, Canada
Patents
- Named inventors: H.Walczak, S. von Karstedt; Methods for treating cancer (publication date 08.01.2015; WO2015001345)
Contact Information
Univ.-Prof. Dr. rer. nat Silvia von Karstedt
Professor (W2)
University of Cologne
Department of Translational Genomics
CECAD Research Center
10 most relevant publications
- Tishina S, Dahlhaus A, Manik M, Mulalic L, Murr J, Kotliar M, Rakhsh-Khorshid H, Kostopoulou M, Hocher F, Stroh J, Beck J, Williams RM, Balta GG, Liu F, Abdallah AT, Bebber CM, Reese M, Lim JKM, Quaas A, Brägelmann J, Pasparakis M, Beleggia F, Balachandran S, Trauzold A, Liccardi G, Astsaturov I, Reichert M, Androulidaki A, von Karstedt S. Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis. Nat Commun. 2026;17(1):5288. doi:10.1038/s41467-026-73189-8
- Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S. Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. Nat Commun. 2025;16(1):11280. doi:10.1038/s41467-025-67142-4
- Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025;32(11):1986-2008. doi:10.1038/s41418-025-01517-4
- Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo González D, Stroh J, Yapici FI, Singh RP, Grotehans N, Langer T, García-Sáez AJ*, von Karstedt S*. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 2025;16(1):40. doi:10.1038/s41419-024-07312-2 *co-correspondence
- Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025;16(1):2951. doi:10.1038/s41467-025-58175-w
- Müller F, Lim JKM, Bebber CM, Seidel E, Tishina S, Dahlhaus A, Stroh J, Beck J, Yapici FI, Nakayama K, Torres Fernández LA, Brägelmann J, Leprivier G, von Karstedt S. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ. 2023;30(2):442-456. doi:10.1038/s41418-022-01096-8
- Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12(1):2048. doi:10.1038/s41467-021-22336-4
- von Karstedt S*, Montinaro A*, Walczak H. Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat Rev Cancer. 2017;17(6):352-366. doi:10.1038/nrc.2017.28 *equal contributions
- Hartwig T*, Montinaro A*, von Karstedt S*, Sevko A, Surinova S, Chakravarthy A, Taraborrelli L, Draber P, Lafont E, Arce Vargas F, El-Bahrawy MA, Quezada SA, Walczak H. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65(4):730-742.e5. doi:10.1016/j.molcel.2017.01.021 *equal contributions
- von Karstedt S, Conti A, Nobis M, Montinaro A, Hartwig T, Lemke J, Legler K, Annewanter F, Campbell AD, Taraborrelli L, Grosse-Wilde A, Coy JF, El-Bahrawy MA, Bergmann F, Koschny R, Werner J, Ganten TM, Schweiger T, Hoetzenecker K, Kenessey I, Hegedüs B, Bergmann M, Hauser C, Egberts JH, Becker T, Röcken C, Kalthoff H, Trauzold A, Anderson KI, Sansom OJ, Walczak H. Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis. Cancer Cell. 2015;27(4):561-573. doi:10.1016/j.ccell.2015.02.014
