CV
Univ. Prof. Dr. rer. nat. Julie George
Academic education
2008 - 2011: PhD, Doctor of Natural Sciences Ruprecht Karl University of Heidelberg, Germany
2005 - 2007: Master of Science in Molecular Life Science Medical University of Lübeck, Germany
2002 - 2005: Bachelor of Science in Molecular Life Science/Biotechnology Medical University of Lübeck, Germany
Scientific career
03/2021- now: Professor for Molecular Head and Neck Oncology (W2)
11/2019 - 03/2021: Research group leader of the Mildred Scheel School of Oncology (MSSO), Department of Translational Genomics, Cologne, Germany
12/2011 - 10/2019: Post-doctoral researcher, University of Cologne/Max Planck Institute of Neurological Research, Department of Translational Genomics, Cologne, Germany
2008 - 2011: PhD student at the German Cancer Research Center, Heidelberg, Germany; Research Group: Innate Immunity and Cancer
04/2007 - 11/2007: Master thesis at the German Cancer Research Center, Heidelberg, Germany; Research Group: Innate Immunity and Cancer
11/2006 - 03/2007: Max Planck Institute for Biophysics, Frankfurt am Main, Germany Research Division: Molecular Membrane biology
06/2006 - 10/2006: University of Madison, WI, USA; Research Division: Institute of Molecular Virology
02/2005 - 07/2005: Bachelor Thesis, Medical University of Lübeck, Lübeck, Germany Research Division: Department of Biochemistry
Honors/ Awards/ Memberships
2016: Young Investigators Award awarded by the International Association for the Study of Lung Cancer (IASLC)
2014: AACR – Scholar in Training Award awarded by the American Association for Cancer Research (AACR)
2011: Postdoctoral Fellowship awarded by the Max Planck society, Germany
2008: PhD 3-year scholarship awarded by the German Cancer Research Center, Heidelberg, Germany
Memberships:
International Association of the Study of Lung Cancer (IASLC)
American Association of Cancer Research (AACR)
European Association of Cancer Research (EACR)
Member of the BMBF-e:Med project committee
10 most relevant publications
- George J (co-corresponding), Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, Reynies AD, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM , Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Lemaitre N, Soltermann A, Weder W, Tischler V, Brustugun OT, Lund-Iversen M, Helland A, Solberg S, Ansén S, Wright G, Solomon B, Roz L, Pastorino U, Petersen I, Clement JH, Sänger J, Wolf J, Vingron M , Zander T, Perner S, Travis WD, Haas SA, Olivier M, Foll M, Büttner R, Hayes DN, Brambilla E, Fernandez-Cuesta L, Thomas RK. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors, Nature Communications. 13, (2018),
- Drapkin B, George J (co-first), Christensen CL, Mino-Kenudson M, Dries R, Sundaresan T, Phat S, Myers DT, Zhong J, Igo P, Hazar-Rethinam MH, Licausi JA, Gomez-Caraballo M, Kem M, Jani KN, Azimi R, Abedpour N, Menon R, Lakis S, Heist RS, Büttner R, Haas S, Sequist LV, Shaw AT, Wong K.-K., Hata AN, Toner M, Maheswaran S, Haber DA, Peifer M, Dyson N, Thomas RK, Farago AF. Genomic and functional fidelity of small cell lung cancer patient-derived xenografts, Cancer Discovery. 26, (2018).
- George J, Saito M2, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK, Kohno T, Genomic amplification of CD274 (PD-L1) in small cell lung cancer. Clinical Cancer Research. 274, (2016).
- George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer P, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Janine Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Yuan Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler K, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Ulrich Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015 Aug 6;524(7563):47-53.
- A. M. Schultheis, A. H. Scheel, L. Ozretić, J. George (co-first), R. K. Thomas, T. Hagemann, T. Zander, J. Wolf, and R. Buettner, PD-L1 expression in small cell neuroendocrine carcinomas, European Journal of Cancer, vol. 51, no. 3, pp. 421–6, Feb. 2015.
- Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z, Solomon B, Petersen I, Clement JH, Sänger J, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Buettner R, Wolf J, Brambilla E, Vingron M, Perner S, Haas SA, Thomas RK. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data, Genome Biology, vol. 16, no. 1, p. 7, Jan. 2015.
- Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozretić L, Seidel D, Zander T, Leenders F, George J, Müller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmüller J, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Ansén S, Stoelben E, Wright GM, Russell P, Wainer Z, Solomon B, Field JK, Hyde R, Davies MP, Heukamp LC, Petersen I, Perner S, Lovly CM, Cappuzzo F, Travis WD, Wolf J, Vingron M, Brambilla E, Haas SA, Buettner R, Thomas RK. Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nature Communications 2014 Mar 27;5:3518.
- Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, and Thomas RK. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genetics 2012 Oct;44(10):1104-10.
- George, J., Motshwene, P.G., Wang, H., Kubarenko, A. V, Rautanen, A., Mills, T.C., Hill, A.V.S., Gay, N.J., and Weber, A.N.R. (2011). Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly. Journal of Biological Chemistry. 2010 286, 1341–1353.
- George, J., Kubarenko, A. V, Rautanen, A., Mills, T.C., Colak, E., Kempf, T., Hill, A.V.S., Nieters, A., and Weber, A.N.R. (2010). MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP. Journal of Immunology. 184, 3025–3032.
Contact Information
Univ. Prof. Dr. rer. nat. Julie George
Professor (W2) for Molecular Head and Neck Oncology
University Hospital of Cologne, University of Cologne Clinics Head and Neck Surgery
Department of Translational Genomics
