CV
Univ. Prof. Dr. rer. nat. Holger Grüll
Academic education
1988 - 1996: Chemistry, University of Cologne
Scientific degrees
12/1996: PhD., University of Cologne, “Untersuchung von Grenzflächenphänomenen der Phasengrenze fest/flüssig in einer binären mischung mit Mischungslücke” (Supervisor: Dietrich Woermann, PhD., Department of Physical Chemistry)
06/1993: Graduation from University of Cologne
Scientific career
2016: Full professor, Department of Radiology University Hospital Cologne, chair experimental imaging and image guided therapy.
2007: Full professor, Facuty of Biomedical Technology, chair molecular imaging and image guided interventions.
2000 - 2016: Principal Scientist Philips Research, Eindhoven, The Netherlands. Head of laboratory for translational research, preclinical imaging and image guided interventions.
1999 - 2000: Postdoctorial fellow, Ben Guiron University of the Negev and Weizmann Institute of Science, Israel (Prof. Dr. Rachel Yerushalmi-Rozen)
1997 - 1999: Postdoctoral fellow, National Institute of Standards and Technology, Gaithersburg, MD, USA (Charles Han, PhD.)
1997: Guest scientist, Ben Guiron University of the Negev, Israel (Prof. Dr. Rachel Yerushalmi-Rozen)
Honors/ Awards/ Memberships
2014: Coordinator of the large scale EU FP7 project IPACT (Image guided Pancreatic Cancer Therapy)
2011: Award for the Most Innovative Research Proposal Area Health, Eindhoven University 2011
2011: teaching Award as best masters docent aof the University Eindhoven
2002: Coordinator of the Dutch STW project “Prospects” (Protein sensing array diagnostics on a chip)
1997: Fellowship of the Alexander von Humboldt Foundation
Contact Information
Univ. Prof. Dr. rer. nat. Holger Grüll
Professor (W2), Experimental Imaging and Image-guided Therapy
University Hospital of Cologne
Department of Radiology
10 most relevant publications
- Werr L, Boland J, Petersen J, Iglesias F, Höppner S, Bartenhagen C, Rosswog C, Hellmann AM, Kahlert Y, Hemstedt N, Ibruli N, Dammert MA, Decarolis B, Werner JM, Malchers F, Schramm K, Witt O, Beiske KH, Rognlien AGW, Gunnes MW, Langenberg KP, Molenaar J, Bernkopf M, Taschner-Mandl S, Hughes D, George SL, Chesler L, Schulte JH, Barone G, Capasso M, Surrey LF, Bagatell R, Masliah-Planchon J, Schleiermacher G, Grüll H, Westermann F, Schultheis AM, Büttner R, Henssen AG, Eggert A, Peifer M, Shukla NN, Simon T, Hero B, Reinhardt HC, Thomas RK, Fischer M. Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma. Journal of Clinical Investigation. 2026;136(7). doi:10.1172/JCI189152
- Kovalyk X, Saniternik S, Hamacher LM, Mink BL, Thoröe-Boveleth S, Bach P, Endres T, Montero-Mirabet M, Schmidt AM, Grüll H. Gelatin and collagen-mimetic nanoparticles for intraperitoneal cisplatin delivery: From synthesis to in-vivo SPECT imaging of biodistribution. Biomaterials Advances. 2026;180:214601. doi:10.1016/j.bioadv.2025.214601
- Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025;646(8087):1243-1253.
doi:10.1038/s41586-025-09434-9
- Rose F, Ibruli O, Lichius L, Kiljan M, Gozum G, Caiaffa MI, Cai J, Niu L na, Herter JM, Grüll H, Büttner R, Beleggia F, Bosco G, George J, Herter-Sprie GS, Reinhardt HC, Bozek K. Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. BMC Res Notes. 2025;18(1):385. doi:10.1186/s13104-025-07460-4
- Meder L, Orschel CI, Bouchez CL, Gholamipoorfard R, Orschel C v., Stahl D, Kreer C, Koker M, Nill M, Kocak IG, Noh KW, Zhao X, Ullrich L, Häupl B, Jakob J, Eich ML, Florin A, Grüll H, Wolf J, Beleggia F, Büttner R, Oellerich T, Klein F, Brägelmann J, Reinhardt HC, Abedpour N, Ullrich RT. ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer. Nat Commun. 2025;16(1):10983. doi:10.1038/s41467-025-66800-x
- Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S. Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. Nat Commun. 2025;16(1):11280. doi:10.1038/s41467-025-67142-4
- Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Torres Fernández LA, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu L na, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024;150(11):496. doi:10.1007/s00432-024-05942-9
- Schmidt P, Lindemeyer J, Raut P, Schütz M, Saniternik S, Jönsson J, Endepols H, Fischer T, Quaas A, Schlößer HA, Thelen M, Grüll H. Multiparametric Characterization of the DSL-6A/C1 Pancreatic Cancer Model in Rats. Cancers (Basel). 2024;16(8):1535. doi:10.3390/cancers16081535
- Nouwens S, Paulides M, Lindemeyer J, Sebeke L, van Kampen R, Grüll H, Heemels M. Simultaneous estimation of SAR, thermal diffusivity, and damping using periodic power modulation for MRgFUS quality assurance. International Journal of Hyperthermia. 2023;40(1). doi:10.1080/02656736.2023.2283388
- Sebeke LC, Castillo Gómez JD, Heijman E, Rademann P, Simon AC, Ekdawi S, Vlachakis S, Toker D, Mink BL, Schubert-Quecke C, Yeo SY, Schmidt P, Lucas C, Brodesser S, Hossann M, Lindner LH, Grüll H. Hyperthermia-induced doxorubicin delivery from thermosensitive liposomes via MR-HIFU in a pig model. Journal of Controlled Release. 2022;343:798-812. doi:10.1016/j.jconrel.2022.02.003
Patents and Patent Filings
- US-2015147273-A1 Radiolabeled analog(s) of compound 0118 and use thereof in connection with pet and/or spect imaging to determine whether a pharmaceutical containing compound 0118 is a candidate cancer treatment for a patient Tilman Lappchen, Holger Grüll, Marc Stefan Robillard, Johan Lub
- US-2011288402-A1 Mr imaging with cest contrast enhancement Jeroen Alphons Pikkemaat, Sander Langereis, Holger Grüll, Dirk Burdinski, Rudolf Mathias Johannes Nicolaas Lamerichs, Jochen Keupp
- US-2010054570-A1 Motion corrected multinuclear magnetic resonance imaging Rudolf Mathias Johannes Nicolaas Lamerichs, Frederik Jan De Bruijn, Holger Grüll, Jochen Keupp
- WO-2010029469-A1 Drug carrier providing mri contrast enhancement Sander Langereis, Jochen Keupp, Holger Grüll, Dirk Burdinski, Danielle Beelen
- US-2009123385-A1 Preparation of dispersions of particles for use as contrast agents in ultrasound imaging Marcel Rene Bohmer, Holger Grüll, Freddy Roozeboom, Antonius Lucien Adrianus Maria Kemmeren
- US-2008193384-A1 Responsive Mri Contrast Agents Nicolaas Petrus Willard, Rene Theodorus Wegh, Jeroen Alphons Pikkemaat, Holger Grüll
- US-2008274057-A1 Staudinger Reaction in Imaging and Therapy and Kits for Use in Imaging and Therapy Marc Stefan Robillard, Holger Grüll
- US-2008200799-A1 Mri Involving Contrast Agent With Time Modulated Contrast Enhancement Nicolaas Petrus Willard, Rene Theodorus Wegh, Jeroen Alphons Pikkemaat, Holger Grüll, Tobias Schaeffter, Rudolf Mathias Johannes Nicolaas Lamerichs
- WO-2006038184-A2 Compounds, kits and methods for use in medical imaging Marc S. Robillard, Holger Grüll
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