Univ. Prof. Dr. rer. nat. Holger Grüll

Academic education

1988 - 1996: Chemistry, University of Cologne

Scientific degrees

12/1996: PhD., University of Cologne, “Untersuchung von Grenzflächenphänomenen der Phasengrenze fest/flüssig in einer binären mischung mit Mischungslücke” (Supervisor: Dietrich Woermann, PhD., Department of Physical Chemistry)
06/1993: Graduation from University of Cologne

Scientific career

2016: Full professor, Department of Radiology University Hospital Cologne, chair experimental imaging and image guided therapy.
2007: Full professor, Facuty of Biomedical Technology, chair molecular imaging and image guided interventions.
2000 - 2016: Principal Scientist Philips Research, Eindhoven, The Netherlands. Head of laboratory for translational research, preclinical imaging and image guided interventions.
1999 - 2000: Postdoctorial fellow, Ben Guiron University of the Negev and Weizmann Institute of Science, Israel (Prof. Dr. Rachel Yerushalmi-Rozen)
1997 - 1999: Postdoctoral fellow, National Institute of Standards and Technology, Gaithersburg, MD, USA (Charles Han, PhD.)
1997: Guest scientist, Ben Guiron University of the Negev, Israel (Prof. Dr. Rachel Yerushalmi-Rozen)

Honors/ Awards/ Memberships

2014: Coordinator of the large scale EU FP7 project IPACT (Image guided Pancreatic Cancer Therapy)
2011: Award for the Most Innovative Research Proposal Area Health, Eindhoven University 2011
2011: teaching Award as best masters docent aof the University Eindhoven
2002: Coordinator of the Dutch STW project “Prospects” (Protein sensing array diagnostics on a chip)
1997: Fellowship of the Alexander von Humboldt Foundation

10 most relevant publications

  • Hijnen H., Kneepkens E., de Smet M., Langereis S., Heijman E. and Grüll H., Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound. PNAS 2017; 114, E4802–E4811.
  • Kneepkens E, Heijman E, Keupp J, Weiss S, Nicolay K, Grüll H. Interleaved Mapping of Temperature and Longitudinal Relaxation Rate to Monitor Drug Delivery During Magnetic Resonance-Guided High-Intensity Focused Ultrasound-Induced Hyperthermia. Invest Radiol. 52(10) 2017; 620-630.
  • Lokerse W. J.M., Bolkestein M., L.M. ten Hagen T., de Jong M., Eggermont A., Grüll H., Koning G.A., Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia, Theranostics 2016; 6, 1717–1731.
  • Starmans L.W.E., Hummelink M.A.P.M., Rossin R., Kneepkens E. C.M., Lamerichs R., Donato K., Nicolay K., Grüll H., 89Zr- and Fe-labeled polymeric micelles for dual modality PET & T1-weighted MR imaging, Advanced Healthcare Materials 2015; 4, 2137–2145.
  • Pedro Gomes Sanches P.G., Peters S., Rossin R., Kaijzel E.L., Que I., Löwik C.W.G.M., and Grüll H., Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies, Bone 2015; 75, 62 – 71.
  • De Vries A., Roessl E., Kneepkens E., Axel Thran A., Brendel B, Martens G., Proksa R., Nicolay K., Grüll H. Quantitative Spectral K-edge imaging in preclinical photon-counting X-ray computed tomography. Investigative Radiology 2015; 50 (4), 297–304
  • Sanches P.G., Rossin R., Böhmer M., Tiemann K., Grüll H., Real-time imaging and kinetics measurements of focused ultrasound-induced extravasation using SPECT/CT, Journal of Controlled Release 2013; 168, 262-270.
  • De Smet M, Langereis S, van den Bosch S, Bitter K, Hijnen N, Heijman E. and Grüll H, SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with High Intensity Focused Ultrasound, Journal of Controlled Release 2013; 169 (1-2), 82-90.
  • van Duijnhven SMJ, Robillard MS, Nicolay K, Grüll H. Tumor Targeting of MMP-2/9 Activatable Cell-Penetrating Imaging Probes Is Caused by Tumor-Independent Activation. Journal of Nuclear Medicine 2011; 52(2), 279-86.
  • de Smet M, Heijman E, Langereis S, Hijnen NM, Grüll H. Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study. J Control Release. 2011 Feb 28;150(1):102-10.

Patents and Patent Filings

  • US-2015147273-A1    Radiolabeled analog(s) of compound 0118 and use thereof in connection with pet and/or spect imaging to determine whether a pharmaceutical containing compound 0118 is a candidate cancer treatment for a patient Tilman Lappchen, Holger Grüll, Marc Stefan Robillard, Johan Lub
  • US-2011288402-A1    Mr imaging with cest contrast enhancement Jeroen Alphons Pikkemaat, Sander Langereis, Holger Grüll, Dirk Burdinski, Rudolf Mathias Johannes Nicolaas Lamerichs, Jochen Keupp
  • US-2010054570-A1    Motion corrected multinuclear magnetic resonance imaging Rudolf Mathias Johannes Nicolaas Lamerichs, Frederik Jan De Bruijn, Holger Grüll, Jochen Keupp
  • WO-2010029469-A1   Drug carrier providing mri contrast enhancement Sander Langereis, Jochen Keupp, Holger Grüll, Dirk Burdinski, Danielle Beelen
  • US-2009123385-A1    Preparation of dispersions of particles for use as contrast agents in ultrasound imaging Marcel Rene Bohmer, Holger Grüll, Freddy Roozeboom, Antonius Lucien Adrianus Maria Kemmeren
  • US-2008193384-A1    Responsive Mri Contrast Agents Nicolaas Petrus Willard, Rene Theodorus Wegh, Jeroen Alphons Pikkemaat, Holger Grüll
  • US-2008274057-A1    Staudinger Reaction in Imaging and Therapy and Kits for Use in Imaging and Therapy Marc Stefan Robillard, Holger Grüll
  • US-2008200799-A1    Mri Involving Contrast Agent With Time Modulated Contrast Enhancement Nicolaas Petrus Willard, Rene Theodorus Wegh, Jeroen Alphons Pikkemaat, Holger Grüll, Tobias Schaeffter, Rudolf Mathias Johannes Nicolaas Lamerichs
  • WO-2006038184-A2   Compounds, kits and methods for use in medical imaging Marc S. Robillard, Holger Grüll

Contact Information

Univ. Prof. Dr. rer. nat. Holger Grüll SFB1399
Univ. Prof. Dr. rer. nat. Holger Grüll

Professor (W2), Experimental Imaging and Image-guided Therapy

University Hospital of Cologne

Department of Radiology

Curriculum Vitae (CV)