CV
Dr. med. Lisa Werr
Academic education
12/2019 Oral State Examination (University of Cologne, Cologne, Germany), Grade: 1.0
10/2018 Written State Examination (University of Cologne, Cologne, Germany), Grade: 1.0
2012 - 2019 Medical School (University of Cologne, Cologne, Germany)
Scientific degrees
08/2023 MD Thesis (Dr. med.): “Die CD74-NRG1-Genfusion ist eine onkogene
Treibermutation” at the Dept. of Translational Genomics, University of Cologne
(Supervisor: Univ.-Prof. Dr. R. Thomas, Grade: Summa Cum Laude, highest honor)
Scientific career
Since 01/2020 Research Assistant at the Dept. of Experimental Pediatric Oncology of the University Hospital Cologne (Head: Univ.-Prof. Dr. M. Fischer)
Since 07/2024 Resident at the Dept. of Pediatrics of the University Hospital Cologne (Director: Univ.-Prof. Dr. J. Dötsch)
Scholarships/ Grants
01/2024 Solving Kids' Cancer UK (SKC) charity´s TRAVEL GRANT for the SIOPEN
Translational Research Meeting
2017 - 2019 Scientific Scholarship by the Köln Fortune Program, University of Cologne
Scholarships/ Grants
10/2023 GPOH young talent prize “Young Oncologist”
05/2023 Best oral presentation, 1st prize (Advances in Neuroblastoma Research (ANR)
Meeting Amsterdam)
Memberships and Scientific Associations
SIOPEN Neuroblastoma Research Network (Verein zur Förderung der Neuroblastomforschung)
GPOH (Gesellschaft für Pädiatrische Onkologie und Hämatologie)
DGKJ (Deutsche Gesellschaft für Kinder- und Jugendmedizin)
Contact Information
Dr. med. Lisa Werr
Junior Group Leader
University Hospital of Cologne
Department of Translational Genomics and Department of Experimental Pediatric
10 Most relevant publications
- Höppner S, Werr L, Szilagyi B, Bartenhagen C, Hellmann AM, Rosswog C, Linden E, Primke G, Kahlert Y, Ibruli N, Hemstedt N, Lorenz W, Brägelmann J, Hölzel M, Fischer M. Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment. Oncoimmunology. 2026;15(1). doi:10.1080/2162402X.2026.2653918
- Werr L, Boland J, Petersen J, Iglesias F, Höppner S, Bartenhagen C, Rosswog C, Hellmann AM, Kahlert Y, Hemstedt N, Ibruli N, Dammert MA, Decarolis B, Werner JM, Malchers F, Schramm K, Witt O, Beiske KH, Rognlien AGW, Gunnes MW, Langenberg KP, Molenaar J, Bernkopf M, Taschner-Mandl S, Hughes D, George SL, Chesler L, Schulte JH, Barone G, Capasso M, Surrey LF, Bagatell R, Masliah-Planchon J, Schleiermacher G, Grüll H, Westermann F, Schultheis AM, Büttner R, Henssen AG, Eggert A, Peifer M, Shukla NN, Simon T, Hero B, Reinhardt HC, Thomas RK, Fischer M. Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma. Journal of Clinical Investigation. 2026;136(7). doi:10.1172/JCI189152
- Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025;646(8087):1243-1253.
doi:10.1038/s41586-025-09434-9
- Werr L, Bartenhagen C, Rosswog C, Cartolano M, Voegele C, Sexton-Oates A, di Genova A, Ernst A, Kahlert Y, Hemstedt N, Höppner S, Mansuet Lupo A, Pelosi G, Brcic L, Papotti M, George J, Bosco G, Quaas A, Tang LH, Robzyk K, Kadota K, Roh MS, Fanaroff RE, Falcon CJ, Büttner R, Lantuejoul S, Rekhtman N, Rudin CM, Travis WD, Alcala N, Fernandez-Cuesta L, Foll M, Peifer M, Thomas RK, Fischer M. TERT Expression and Clinical Outcome in Pulmonary Carcinoids. Journal of Clinical Oncology. 2025;43(2):214-225. doi:10.1200/JCO.23.02708
- Werr L, Rosswog C, Bartenhagen C, George SL, Fischer M. Telomere maintenance mechanisms in neuroblastoma: New insights and translational implications. EJC Paediatric Oncology. 2024;3:100156. doi:10.1016/j.ejcped.2024.100156
- George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK. Evolutionary trajectories of small cell lung cancer under therapy. Nature. 2024;627(8005):880-889. doi:10.1038/s41586-024-07177-7
- Meeser A, Bartenhagen C, Werr L, Hellmann AM, Kahlert Y, Hemstedt N, Nürnberg P, Altmüller J, Ackermann S, Hero B, Simon T, Peifer M, Fischer M, Rosswog C. Reliable assessment of telomere maintenance mechanisms in neuroblastoma. Cell Biosci. 2022;12(1):160. doi:10.1186/s13578-022-00896-2
- Fischer-Mertens J, Otte F, Roderwieser A, Rosswog C, Kahlert Y, Werr L, Hellmann AM, Berding M, Chiu B, Bartenhagen C, Fischer M. Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models. Cellular Oncology. 2022;45(5):991-1003. doi:10.1007/s13402-022-00702-8
- Lategahn J, Tumbrink HL, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, Keul M, Parmaksiz F, Baumann M, Menninger S, Zent E, Landel I, Weisner J, Jeyakumar K, Heyden L, Russ N, Müller F, Lorenz C, Brägelmann J, Spille I, Grabe T, Müller MP, Heuckmann JM, Klebl BM, Nussbaumer P, Sos ML, Rauh D. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65(9):6643-6655. doi:10.1021/acs.jmedchem.1c02080
- Werr L, Plenker D, Dammert MA, Lorenz C, Brägelmann J, Tumbrink HL, Klein S, Schmitt A, Büttner R, Persigehl T, Shokat KM, Wunderlich FT, Schram AM, Peifer M, Sos ML, Reinhardt HC, Thomas RK. CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization. Mol Cancer Ther. 2022;21(5):821-830. doi:10.1158/1535-7163.MCT-21-0820
