Dr. phil. nat. Robert Hänsel-Hertsch

Academic education

6/2013 - 11/2013: Cancer Research UK Cambridge Institute, University of Cambridge, UK
2009 - 2013: PhD thesis work, Goethe University, Department of Biophysical Chemistry, Frankfurt/Main, Germany
1/2012 - 3/2012: University of Tokyo, Grad. School of Pharm. Sciences, Japan (JSPS Predoctoral Fellowship)
2003 - 2009: Diploma thesis work, Goethe University, Frankfurt/Main, Germany

Scientific degree

2013: PhD degree in Biochemistry, Goethe University, Department of Biophysical Chemistry, Frankfurt/Main, Germany
2009: Diploma degree in Biochemistry, Goethe University, Frankfurt/Main, Germany

Professional experience

8/2013 - present: Junior research group leader, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
11/2013 - 7/2019: EMBO, Herchel-Smith and Postdoctoral Fellow, Cancer Research UK Cambridge Institute, University of Cambridge, UK

Service to scientific community, honours and fellowships

3/2020 - present: EMBO Short Term Fellowship Committee
2017 - 2019: Herchel Smith Postdoc-Fellowship
2013 - 2015: EMBO Long-Term Fellowship
2013: DAAD Postdoc-Fellowship (not accepted)
2011: JSPS Predoctoral Fellowship (short-term) for North American and European Researchers
2011: Richard-Ernst-Award for innovative contributions within the magnetic resonance field
2010 - 2012: Fund of the Chemical Industry PhD fellowship
2009 - 2010: Procter & Gamble Award for best diploma work in Biochemistry

10 most relevant publications

  • Hänsel-Hertsch R, Simeone A, Shea A, Hui WWI, Zyner KG, Marsico G, Rueda OM, Bruna A, Martin A, Zhang X, Adhikari S, Tannahill D, Caldas C & Balasubramanian S (2020) Landscape of G-quadruplex DNA structural regions in breast cancer. Nat. Genet., accepted
  • Mao S-Q, Ghanbarian AT, Spiegel J, Martínez Cuesta S, Beraldi D, Di Antonio M, Marsico G, Hänsel-Hertsch R, Tannahill D & Balasubramanian S (2018) DNA G-quadruplex structures mold the DNA methylome. Nat. Struct. Mol. Biol.25: 951–957
  • Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA & Narita M (2018) NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat. Commun.9
  • Hänsel-Hertsch R, Spiegel J, Marsico G, Tannahill D & Balasubramanian S (2018) Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing. Nat. Protoc.13: 551–564
  • Hänsel-Hertsch R, Antonio M Di & Balasubramanian S (2017) DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential. Nat. Rev. Mol. Cell Biol.18: 279–284
  • Hänsel-Hertsch R, Beraldi D, Lensing S V, Marsico G, Zyner K, Parry A, Di Antonio M, Pike J, Kimura H, Narita M, Tannahill D & Balasubramanian S (2016) G-quadruplex structures mark human regulatory chromatin. Nat. Genet.48: 1267–72
  • Lensing S V, Marsico G, Hänsel-Hertsch R, Lam EY, Tannahill D & Balasubramanian S (2016) DSBCapture: in situ capture and sequencing of DNA breaks. Nat. Methods13: 1–6
  • Hänsel R (co-corresponding), Löhr F, Trantirek L & Dötsch V (2013) High-Resolution Insight into G-Overhang Architecture. J. Am. Chem. Soc.135: 2816–2824
  • Hänsel R, Löhr F, Foldynová-Trantírková S, Bamberg E, Trantírek L & Dötsch V (2011) The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions. Nucleic Acids Res.39: 5768–5775
  • Hänsel R, Foldynová-Trantírková S, Löhr F, Buck J, Bongartz E, Bamberg E, Schwalbe H, Dötsch V & Trantírek L (2009) Evaluation of Parameters Critical for Observing Nucleic Acids Inside Living Xenopus laevis Oocytes by In-Cell NMR Spectroscopy. J. Am. Chem. Soc.131: 15761–15768

Contact Information

Dr. phil. nat. Robert Hänsel-Hertsch SFB1399
Dr. phil. nat. Robert Hänsel-Hertsch

Junior research group leader

University of Cologne

Center for Molecular Medicine Cologne

Curriculum Vitae (CV)