A05

Immuno-editing via programmed cell death in SCLC

In A05, S. von Karstedt will address the timely question of how   evolution of SCLC is shaped by adaptive immunity-mediated selection   before clinical presentation. By understanding fundamental mechanisms   of SCLC immune-selection and escape, novel avenues for therapeutic   intervention will be identified. Based on the understanding that   chemo-naïve SCLC has gone through intense negative selection against   extrinsic apoptosis pathway components and antigen presentation, both   known to be involved in immune-escape, the development of SCLC in the   presence or absence of immune system-mediated selection will be   studied mechanistically in vitro and in vivo.

Principal Investigator

Ph.D. Silvia von Karstedt SFB1399
Ph.D. Silvia von Karstedt

Max Eder Junior Research Group Leader

University of Cologne

Department of Translational Genomics

CECAD Research Center 

Curriculum Vitae (CV)

A05