In A05, S. von Karstedt will address the timely question of how evolution of SCLC is shaped by adaptive immunity-mediated selection before clinical presentation. By understanding fundamental mechanisms of SCLC immune-selection and escape, novel avenues for therapeutic intervention will be identified. Based on the understanding that chemo-naïve SCLC has gone through intense negative selection against extrinsic apoptosis pathway components and antigen presentation, both known to be involved in immune-escape, the development of SCLC in the presence or absence of immune system-mediated selection will be studied mechanistically in vitro and in vivo.
University of Cologne
Department of Translational Genomics
CECAD Research Center