Molecular characterization of the immunogenic profile in SCLC tumors

In C01 J. George will perform a molecular characterization of the immunogenic landscape in a large cohort of SCLC patients. Single cell transcriptome sequencing and proteome profiling will be performed on tumor and immune cells to thus decipher the identity and quantity of immune cells within the tumor, as well as in the peripheral blood. Taken together, these comprehensive approaches will provide mechanistic insight on how somatic alteration patterns in SCLC impact their immunogenic profile and thus therapeutic responses in a comprehensive fashion.

Principal Investigator

Univ. Prof. Dr. rer. nat. Julie George SFB1399
Univ. Prof. Dr. rer. nat. Julie George

Professor (W2) for Molecular Head and Neck Oncology

University Hospital of Cologne, University of Cologne Clinics Head and Neck Surgery

Department of Translational Genomics

Curriculum Vitae (CV)