B06

Junior research project: Dynamics of mutational signatures activities in SCLC

Mutational signatures analysis is routinely applied in cancer genomic studies to identify endogenous and exogenous sources of mutagenesis operating in cancer. DNA damage induced by the exposure of tobacco carcinogens is, among others, one the most prominent mutational signature identified in treatment naïve SCLC samples. In B06, M. Cartolano will provide a detailed characterization of the mutational signatures operating in SCLC described in the context of the cell of origin and exposure to cigarette smoke. Given that the relevance of these mutational processes for the evolution of the SCLC phenotype is largely unexplored, M.Cartolano will then explore how evolving mutational processes correlate with the acquisition of resistance mechanisms to therapy and metastatic spreading.

Principal Investigator

Dr. nat. med. Maria Cartolano SFB1399
Dr. nat. med. Maria Cartolano

Junior research group leader

University of Cologne

Department of Translational Genomics

Curriculum Vitae (CV)

Project Interactions

B06