Mechanisms of drug sensitivity and resistance in SCLC

In B01, R. Thomas will generate pairs of drug sensitive and resistant SCLC models with the goal of performing in-depth molecular studies to identify mechanisms of drug resistance. He will perform high-coverage exome and transcriptome sequencing with the goal of identifying genomic alterations that govern transition to the drug resistant state. Since transcriptional intratumor heterogeneity has been described previously to occur in SCLC with the expression of two orthogonal developmental master programs, R. Thomas will conduct single cell sequencing of the various models in order to link a particular phenotype to the dominance of a given transcriptional profile. 

Principal Investigator

Univ. Prof. Dr. med. Roman K. Thomas SFB1399
Univ. Prof. Dr. med. Roman K. Thomas

Professor (W3) and Director of the Department of Translational Genomics

University of Cologne

Department of Translational Genomics

Curriculum Vitae (CV)