Dr. med. Anne M. Schultheis

Academic education

2003 - 2011: Medical School, University of Cologne, University of Geneva (CH),University of Zurich (CH)

Scientific degrees

06/2011: M.D., Medical School, University of Cologne, Magna cum Laude: “Angiogenese Gen-Polymorphismen als molekulare Marker für die Rezidivenstehung im Stadium III Kolonkarzinom” (Supervisor: Arnulf H. Hoelscher, M.D. Department for General-Visceral- and Tumorsurgery, University of Cologne)
06/2011: Graduation from Medical School, University of Cologne, Magna cum Laude

Scientific career

2016 - present: Independent group leader, “Molecular Pathology”, Department of Pathology University of Cologne
2014 - 2015: Postdoctoral research fellow, Memorial Sloan Kettering Cancer Center, Experimental Pathology, New York, USA (Group of Jorge S. Reis-Filho, M.D., PhD)
09-12/2008: Research intern, Centre for Cancer and Inflammation Barts Cancer Institute, Queen Mary University London, UK (Group of Professor Francis Balkwill, OBE, FMedSci)
2005 - 2006: Undergraduate research fellow, USC Norris Comprehensive Cancer Center, Division of medical oncology, Los Angeles, USA (Group of Professor Heinz-Josef Lenz, M.D.)

Honors/ Awards/ Memberships

2014: Mildred-Scheel stipend of the German Cancer Aid
2011: “Die Besten für die Allgemein- und Viszeralchirurgie”, awarded by the German society for general and visceral surgery for the best doctor thesis in 2011

10 Most relevant publications

  • Castiglione R, Alidousty C, Holz B, Wagener S, Baar T, Heydt C, Binot E, Zupp S, Kron A, Wolf J, Merkelbach-Bruse S, Reinhardt HC, Buettner R, Schultheis AM. Comparison of the genomic background of MET-altered carcinomas of the lung: biological differences and analogies. Mod Pathol. 2018 Nov 20.
  • Kron A, Alidousty C, Scheffler M, Merkelbach-Bruse S, Seidel D, Riedel R, Ihle MA, Michels S, Nogova L, Fassunke J, Heydt C, Kron F, Ueckeroth F, Serke M, Krüger S, Grohe C, Koschel D, Benedikter J, Kaminsky B, Schaaf B, Braess J, Sebastian M, Kambartel KO, Thomas R, Zander T, Schultheis AM, Büttner R, Wolf J. Impact of TP53 mutation status on systemic treatment outcome in ALK-rearranged non-small-cell lung cancer. Ann Oncol. 2018 Oct 1;29(10):2068-2075.
  • Alidousty C, Baar T, Martelotto LG, Heydt C, Wagener S, Fassunke J, Duerbaum N, Scheel AH, Frank S, Holz B, Binot E, Kron A, Merkelbach-Bruse S, Ihle MA, Wolf J, Buettner R, Schultheis AM. Genetic instability and recurrent MYC amplification in ALK-translocated NSCLC: a central role of TP53 mutations. J Pathol. 2018 Sep;246(1):67-76.
  • Schultheis AM, Ng CK, De Filippo MR, Piscuoglio S, Macedo GS, Gatius S, Perez Mies B, Soslow RA, Lim RS, Viale A, Huberman KH, Palacios JC, Reis-Filho JS, Matias-Guiu X, Weigelt B. Massively Parallel Sequencing-Based Clonality Analysis of Synchronous Endometrioid Endometrial and Ovarian Carcinomas. J Natl Cancer Inst. 2016 Feb 1;108(6):djv427.
  • Scheel AH, Ansén S, Schultheis AM, Scheffler M, Fischer RN, Michels S, Hellmich M, George J, Zander T, Brockmann M, Stoelben E, Groen H, Timens W, Perner S, von Bergwelt-Baildon M, Büttner R, Wolf J.PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations. Oncoimmunology. 2016 Mar 16;5(5):e1131379
  • Schultheis AM, Martelotto LG, De Filippo MR, Piscuglio S, Ng CK, Hussein YR, Reis-Filho JS, Soslow RA, Weigelt B.TP53 Mutational Spectrum in Endometrioid and Serous Endometrial Cancers.Int J Gynecol Pathol. 2016 Jul;35(4):289-300
  • Schultheis AM, Scheel AH, Ozretić L, George J, Thomas RK, Hagemann T, Zander T, Wolf J, Buettner R. PD-L1 expression in small cell neuroendocrine carcinomas. Eur J Cancer. 2015 Feb;51(3):421-6.
  • Schildhaus HU, Schultheis AM, Rüschoff J, Binot E, Merkelbach-Bruse S, Fassunke J, Schulte W, Ko YD, Schlesinger A, Bos M, Gardizi M, Engel-Riedel W, Brockmann M, Serke M, Gerigk U, Hekmat K, Frank KF, Reiser M, Schulz H, Krüger S, Stoelben E, Zander T, Wolf J, Buettner R. MET amplification status in therapy-naïve adeno- and squamous cell carcinomas of the lung. Clin Cancer Res. 2015 Feb 15;21(4):907-15.
  • Schultheis AM, Bos M, Schmitz K, Wilsberg L, Binot E, Wolf J, Büttner R, Schildhaus HU. Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer.Mod Pathol. 2014 Feb;27(2):214-21
  • Schultheis AM, Lurje G, Rhodes KE, Zhang W, Yang D, Garcia AA, Morgan R, Gandara D, Scudder S, Oza A, Hirte H, Fleming G, Roman L, Lenz HJ. Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res. 2008 Nov 15;14(22):7554-63

Contact Information

PD Dr. med. Anne M. Schultheis SFB1399
PD Dr. med. Anne M. Schultheis

Group Leader, Pathology Resident

University Hospital of Cologne

Department of Pathology

Curriculum Vitae (CV)